GNH USA

Europe — EMA

Lenalidomid Zentiva

GNH USA supplies Lenalidomid Zentiva (Lenalidomide), an immunomodulatory drug for myeloma, del(5q) MDS and mantle cell lymphoma. Request a quote for supply.

Lenalidomide

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What is Lenalidomide?

Lenalidomide, the active ingredient in Lenalidomid Zentiva, is an immunomodulatory imide drug (IMiD) presented as a tablet for oral use. It treats multiple myeloma, myelodysplastic syndromes with del(5q), and mantle cell lymphoma in adult patients.

GNH USA supplies Lenalidomid Zentiva as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies and clinics worldwide.

What is Lenalidomide used for?

Lenalidomide is used in hematologic malignancies and related disorders, targeting abnormal cell growth and immune dysregulation. - Multiple myeloma: improves progression‑free survival and overall response rates in adult patients. - Myelodysplastic syndromes with del(5q): reduces transfusion dependence and improves blood counts. - Mantle cell lymphoma: contributes to disease control when combined with other agents in adult patients.

What are the side effects of Lenalidomide?

Lenalidomide may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects: - Fatigue: persistent tiredness. - Diarrhea: loose stools. - Nausea: upset stomach. - Rash: skin irritation.

Serious or Rare Side Effects: - Thromboembolic events: deep vein thrombosis or pulmonary embolism. - Severe neutropenia: markedly low neutrophil count. - Secondary malignancies: emergence of new cancers. - Hepatotoxicity: liver enzyme elevations or liver injury.

What precautions apply to Lenalidomide?

Before initiating therapy, several safety measures should be observed. - Monitor blood counts: regular CBC to detect neutropenia or thrombocytopenia. - Assess thrombotic risk: evaluate history of clotting disorders before therapy. - Avoid pregnancy: use effective contraception due to teratogenic potential. - Adjust for renal impairment: dose may need modification in reduced kidney function. - Store at ambient temperature: keep tablets below 25°C in original packaging, protect from moisture.

What does Lenalidomide interact with?

Lenalidomide can interact with other medicines, requiring careful management.

Major Interactions (Avoid): - Strong CYP3A4 inducers: may reduce lenalidomide exposure. - Anticoagulants (warfarin, DOACs): increased risk of bleeding or clotting complications.

Moderate Interactions (Monitor Closely): - P-glycoprotein inhibitors: may increase plasma levels. - Immunosuppressants (e.g., cyclosporine): may enhance immunomodulatory effects. - Vaccines: live vaccines may be less effective; avoid during therapy.

Frequently asked questions

What is Lenalidomid Zentiva used for?+
Lenalidomid Zentiva contains lenalidomide, an immunomodulatory imide drug indicated for the treatment of adult patients with multiple myeloma, myelodysplastic syndromes that have a deletion of chromosome 5q (del(5q)), and mantle cell lymphoma. It is prescribed as part of a therapeutic regimen to control disease progression, improve blood counts, and extend survival in these hematologic malignancies.
How does lenalidomide work?+
Lenalidomide binds to the cereblon component of the CRL4‑CRBN E3 ubiquitin ligase complex, altering its substrate specificity. This triggers ubiquitination and proteasomal degradation of transcription factors such as Ikaros and Aiolos, leading to anti‑angiogenic, immunomodulatory, and anti‑proliferative effects that suppress malignant plasma cells and other cancerous cells in the bone marrow.
What is the usual dose of lenalidomide?+
The dosage of lenalidomide is individualized by the prescribing physician based on the specific indication, disease stage, renal function, and patient tolerance. The prescriber determines the appropriate strength, frequency, and duration of therapy, and any dose adjustments are made according to clinical response and laboratory monitoring.
Is lenalidomide safe during pregnancy or breastfeeding?+
Lenalidomide is classified as having unknown pregnancy category and is considered teratogenic in animal studies. It should not be used by pregnant women, and effective contraception is required for both male and female patients of reproductive potential. Breastfeeding is not recommended while receiving lenalidomide because the drug may be excreted in milk.
How do I order Lenalidomid Zentiva from GNH USA?+
To place an order, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity of Lenalidomid Zentiva. GNH USA works with hospitals, pharmacies, and procurement teams worldwide, and will request verification of trade or institutional credentials. The sales team then provides pricing, availability, shipping details and assists with any necessary import documentation.
How does lenalidomide compare with its main alternative drug?+
The primary alternative to lenalidomide in many hematologic cancers is thalidomide, another immunomodulatory imide drug. Lenalidomide generally offers a more favorable safety profile, with lower rates of peripheral neuropathy, and stronger anti‑angiogenic and immune‑activating effects. However, both agents share risks such as thromboembolic events and require careful monitoring.
What are the storage and handling requirements for Lenalidomid Zentiva?+
Lenalidomid Zentiva tablets should be stored at ambient temperature, below 25 °C, in the original blister pack to protect them from moisture and light. Keep the medication out of reach of children and do not use if the packaging is damaged or the tablets appear discoloured.
How is Lenalidomid Zentiva administered?+
Lenalidomid Zentiva is taken orally, usually with or without food, as directed by the prescribing clinician. Patients should swallow the tablet whole with a full glass of water and follow any specific timing instructions related to other concomitant medications to avoid potential interactions.
What are the most serious risks associated with lenalidomide therapy?+
The most serious adverse events linked to lenalidomide include severe neutropenia and thrombocytopenia, which can increase infection and bleeding risk, as well as thromboembolic events such as deep‑vein thrombosis or pulmonary embolism. Rarely, secondary malignancies and significant liver injury may occur, requiring regular laboratory monitoring and prompt medical attention if symptoms arise.
Who should not use Lenalidomid Zentiva?+
Lenalidomid Zentiva is contraindicated in patients with known hypersensitivity to lenalidomide or any component of the tablet. It should also be avoided in individuals with active, uncontrolled infections, severe renal impairment without dose adjustment, and in pregnant or nursing women. Clinicians must evaluate each patient’s medical history before initiating therapy.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Lenalidomide
Route
Oral Use
Manufacturer
Zentiva, K.S.
Origin
EU

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