GNH USA

Europe — EMA

Lenalidomid Piramal

GNH USA supplies Lenalidomid Piramal (Lenalidomide), a immunomodulatory drug for multiple myeloma, myelodysplastic syndromes and mantle cell lymphoma.

Lenalidomide

Request sourcing

1
Pack/s

What is Lenalidomide?

Lenalidomide, the active ingredient in Lenalidomid Piramal, is an immunomodulatory drug (IMiD) presented as a tablet for oral use. It is used to treat certain blood cancers such as multiple myeloma, myelodysplastic syndromes, and mantle cell lymphoma in adult patients.

GNH USA supplies Lenalidomid Piramal as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies and clinics worldwide.

What is Lenalidomide used for?

Lenalidomide is employed in hematologic malignancies that involve abnormal plasma or lymphoid cells.

Multiple myeloma: improves progression‑free survival and overall response rates. Myelodysplastic syndromes: reduces transfusion dependence and improves blood counts. Mantle cell lymphoma: induces tumor regression and prolongs remission.

What are the side effects of Lenalidomide?

Lenalidomide may cause a range of adverse reactions that vary in frequency and severity.

Common Side Effects: - Fatigue - Neutropenia - Thrombocytopenia - Anemia - Diarrhea - Rash

Serious or Rare Side Effects: - Venous thromboembolism - Secondary primary malignancies - Severe cutaneous reactions (e.g., Stevens‑Johnson syndrome) - Hepatic toxicity - Tumor lysis syndrome - Severe neutropenia with infection risk

What precautions apply to Lenalidomide?

Lenalidomide requires careful monitoring and specific safety measures.

Pregnancy: Contraindicated (Category X); ensure effective contraception. Thrombosis risk: Assess need for prophylactic anticoagulation. Blood counts: Perform regular CBC monitoring. Renal impairment: Adjust dose based on renal function. Hepatic impairment: Monitor liver enzymes periodically. Store at ambient temperature: Keep below 25°C, retain in original packaging, protect from moisture.

What does Lenalidomide interact with?

Lenalidomide can interact with several drug classes, requiring vigilance.

Major Interactions (Avoid): - Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin) may increase exposure. - Strong CYP3A4 inducers (e.g., rifampin, phenytoin) may reduce efficacy. - Anticoagulants (e.g., warfarin) may heighten bleeding risk.

Moderate Interactions (Monitor Closely): - NSAIDs: may augment thrombosis risk. - Live vaccines: contraindicated due to immunosuppression.

Frequently asked questions

What conditions is Lenalidomid Piramal used for?+
Lenalidomid Piramal contains lenalidomide, which is indicated for the treatment of adult patients with multiple myeloma, myelodysplastic syndromes that have deletion 5q, and mantle cell lymphoma. These are hematologic cancers where the drug helps control disease progression and improve response rates.
How does lenalidomide work in the body?+
Lenalidomide binds to cereblon, a component of the CRL4‑E3 ubiquitin ligase complex, leading to the targeted degradation of transcription factors Ikaros and Aiolos. This action modulates the immune system, inhibits new blood‑vessel formation, and exerts direct anti‑proliferative effects on malignant plasma and lymphoid cells.
What is the usual dose of Lenalidomid Piramal?+
The specific dose of Lenalidomid Piramal is determined by the prescribing clinician based on the patient’s diagnosis, disease stage, renal function, and other individual factors. Healthcare professionals follow approved labeling and clinical guidelines to set an appropriate regimen.
Is Lenalidomid Piramal safe during pregnancy or breastfeeding?+
Lenalidomid Piramal is classified as Pregnancy Category X, meaning it is contraindicated in pregnancy due to a high risk of fetal harm. Women of childbearing potential must use effective contraception, and breastfeeding is not recommended while taking the medication.
How do I order Lenalidomid Piramal from GNH USA?+
To place an order, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.
How does lenalidomide compare with its main alternative, thalidomide?+
Both lenalidomide and thalidomide belong to the immunomodulatory drug class, but lenalidomide is more potent, has a broader spectrum of activity, and generally exhibits a more favorable safety profile, especially regarding peripheral neuropathy. Clinical guidelines often prefer lenalidomide for the approved indications listed.
What are the recommended storage conditions for Lenalidomid Piramal?+
Lenalidomid Piramal should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original container, protect it from moisture and direct sunlight, and ensure the packaging remains sealed until use.
How is Lenalidomid Piramal administered?+
The medication is taken orally, usually as a tablet, with or without food as directed by the prescriber. Patients should swallow the tablet whole and follow the dosing schedule provided by their healthcare professional.
What are the most serious risks associated with Lenalidomid Piramal?+
Serious risks include venous thromboembolism, severe neutropenia leading to infection, secondary primary malignancies, and rare but severe skin reactions such as Stevens‑Johnson syndrome. Patients should be monitored closely for signs of these events and report any concerning symptoms promptly.
Who should not use Lenalidomid Piramal?+
Lenalidomid Piramal is contraindicated in pregnant women, individuals with known hypersensitivity to lenalidomide or its excipients, and patients with uncontrolled severe infections. Caution is also advised for those with significant renal or hepatic impairment, and the drug should be avoided in patients receiving live vaccines.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
Send a sourcing enquiry for this product →

Product details

Drug
Lenalidomide
Route
Oral Use
Manufacturer
Piramal Critical Care B.V.
Origin
EU

Related products

A

A

Liquid Extract From Viscum Album Subsp. Abietis Var Abies Alba (1:20), Extraction Solvents: Water Fo

Helixor Heilmittel Gmbh
EU
A

A

Liquid Extract From Viscum Album Subsp. Abietis Var Abies Alba (1:20), Extraction Solvents: Water Fo

Helixor Heilmittel Gmbh
EU
A

A

Liquid Extract From Viscum Album Subsp. Abietis Var Abies Alba (1:20), Extraction Solvents: Water Fo

Helixor Heilmittel Gmbh
EU
A

A

Liquid Extract From Viscum Album Subsp. Abietis Var Abies Alba (1:20), Extraction Solvents: Water Fo

Helixor Heilmittel Gmbh
EU