Lekofusin

Ibuprofen/Paracetamol, the active ingredient in Lekofusin, is a Nonsteroidal anti-inflammatory drug presented as an oral formulation for oral use. It is indicated for the relief of pain, reduction of fever, and mitigation of inflammation in adult patients.\n\nGNH India supplies Lekofusin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Lekofusin combines ibuprofen and paracetamol to act on pain‑related and febrile pathways.\n\nPain: Provides analgesic relief for mild to moderate acute pain such as headache or musculoskeletal discomfort.\nFever: Reduces elevated body temperature associated with viral or bacterial infections.\nInflammation: Decreases localized swelling and discomfort in conditions like minor injuries or arthritic flare‑ups.

Adverse reactions may occur with oral ibuprofen/paracetamol combinations.\n\nCommon Side Effects:\n- Nausea or upset stomach\n- Dyspepsia or heartburn\n- Headache\n- Dizziness\n- Mild skin rash\n- Transient elevation of liver enzymes\n\nSerious or Rare Side Effects:\n- Gastrointestinal bleeding or ulceration\n- Severe hepatic injury\n- Stevens‑Johnson syndrome or toxic epidermal necrolysis\n- Anaphylactic reaction\n- Renal impairment or acute kidney injury\n- Blood dyscrasias such as agranulocytosis

Before using Lekofusin, consider the following safety measures.\n\nRenal function assessment: Evaluate kidney health, especially in patients with chronic renal disease.\nHepatic function assessment: Monitor liver enzymes in patients with existing liver conditions.\nHypersensitivity: Avoid if known allergy to ibuprofen, paracetamol, or other NSAIDs.\nAnticoagulant use: Use caution when combined with warfarin or other blood thinners due to bleeding risk.\nPregnancy trimester: Avoid in the third trimester because of potential fetal complications.\nStore at ambient temperature: Keep below 25 °C in the original packaging, protected from moisture and direct sunlight.

Lekofusin may interact with several drug classes.\n\nMajor Interactions (Avoid):\n- Anticoagulants (e.g., warfarin) – increased bleeding risk\n- Other NSAIDs or aspirin – additive gastrointestinal toxicity\n- Lithium – elevated lithium serum levels\n- Methotrexate – reduced clearance leading to toxicity\n- SSRIs or SNRIs – heightened risk of gastrointestinal bleeding\n\nModerate Interactions (Monitor Closely):\n- Antihypertensives – possible reduction in blood pressure effect\n- Diuretics – may impair renal excretion of ibuprofen\n- ACE inhibitors – risk of reduced renal function\n- Corticosteroids – increased ulcer risk\n- Alcohol – potentiates liver toxicity and gastric irritation