Lekofen

Ibuprofen and Paracetamol, the active ingredients in Lekofen, are NSAID and analgesic agents presented as an oral tablet for systemic use. They are used to relieve pain and reduce fever in adults and children.

GNH USA supplies Lekofen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Lekofen combines ibuprofen and paracetamol to address pain and fever through peripheral and central mechanisms.

- Pain: provides effective analgesia for mild to moderate discomfort. - Fever: lowers elevated body temperature. - Headache: alleviates tension‑type and migraine‑associated headache. - Musculoskeletal pain: eases inflammation‑related aches in joints and muscles.

Adverse reactions may occur with oral ibuprofen/paracetamol combinations.

Common Side Effects: - Gastrointestinal discomfort or dyspepsia. - Nausea or vomiting. - Dizziness or light‑headedness. - Mild skin rash or itching.

Serious or Rare Side Effects: - Severe allergic reactions such as anaphylaxis. - Hepatic injury, including elevated liver enzymes. - Acute kidney injury or reduced renal function. - Gastrointestinal bleeding or ulcer perforation.

Use Lekofen with awareness of specific safety considerations.

- Assess renal function: avoid in severe renal impairment. - Monitor hepatic status: caution in patients with liver disease. - Avoid concurrent NSAIDs: increased risk of gastrointestinal toxicity. - Limit alcohol consumption: may enhance hepatotoxic potential. - Pregnancy and breastfeeding: consult a healthcare professional before use. - Store at ambient temperature: keep in the original pack, protect from moisture and direct sunlight.

Lekofen may interact with several drug classes, requiring careful management.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): heightened bleeding risk. - Other NSAIDs or COX‑2 inhibitors: additive gastrointestinal toxicity. - High‑dose corticosteroids: increased ulcer potential. - Lithium: ibuprofen can raise serum lithium levels. - Methotrexate: ibuprofen may reduce methotrexate clearance.

Moderate Interactions (Monitor Closely): - ACE inhibitors or ARBs: possible renal function alteration. - Diuretics: risk of reduced renal perfusion. - SSRIs: combined use may increase bleeding tendency. - Alcohol: synergistic hepatotoxic effect. - Anticonvulsants (e.g., carbamazepine): may affect drug metabolism.