GNH USA

Europe — EMA

Lekofen (Ibuprofen, Paracetamol)

GNH USA supplies Lekofen (Ibuprofen/Paracetamol), a NSAID/analgesic for pain, fever and headache. Request a quote for global supply. to clinics worldwide.

Ibuprofen, Paracetamol

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What is Ibuprofen, Paracetamol?

Ibuprofen and Paracetamol, the active ingredients in Lekofen, are NSAID and analgesic agents presented as an oral tablet for systemic use. They are used to relieve pain and reduce fever in adults and children.

GNH USA supplies Lekofen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Ibuprofen, Paracetamol used for?

Lekofen combines ibuprofen and paracetamol to address pain and fever through peripheral and central mechanisms.

- Pain: provides effective analgesia for mild to moderate discomfort. - Fever: lowers elevated body temperature. - Headache: alleviates tension‑type and migraine‑associated headache. - Musculoskeletal pain: eases inflammation‑related aches in joints and muscles.

What are the side effects of Ibuprofen, Paracetamol?

Adverse reactions may occur with oral ibuprofen/paracetamol combinations.

Common Side Effects: - Gastrointestinal discomfort or dyspepsia. - Nausea or vomiting. - Dizziness or light‑headedness. - Mild skin rash or itching.

Serious or Rare Side Effects: - Severe allergic reactions such as anaphylaxis. - Hepatic injury, including elevated liver enzymes. - Acute kidney injury or reduced renal function. - Gastrointestinal bleeding or ulcer perforation.

What precautions apply to Ibuprofen, Paracetamol?

Use Lekofen with awareness of specific safety considerations.

- Assess renal function: avoid in severe renal impairment. - Monitor hepatic status: caution in patients with liver disease. - Avoid concurrent NSAIDs: increased risk of gastrointestinal toxicity. - Limit alcohol consumption: may enhance hepatotoxic potential. - Pregnancy and breastfeeding: consult a healthcare professional before use. - Store at ambient temperature: keep in the original pack, protect from moisture and direct sunlight.

What does Ibuprofen, Paracetamol interact with?

Lekofen may interact with several drug classes, requiring careful management.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): heightened bleeding risk. - Other NSAIDs or COX‑2 inhibitors: additive gastrointestinal toxicity. - High‑dose corticosteroids: increased ulcer potential. - Lithium: ibuprofen can raise serum lithium levels. - Methotrexate: ibuprofen may reduce methotrexate clearance.

Moderate Interactions (Monitor Closely): - ACE inhibitors or ARBs: possible renal function alteration. - Diuretics: risk of reduced renal perfusion. - SSRIs: combined use may increase bleeding tendency. - Alcohol: synergistic hepatotoxic effect. - Anticonvulsants (e.g., carbamazepine): may affect drug metabolism.

Frequently asked questions

What conditions is Lekofen used for?+
Lekofen is indicated for the temporary relief of mild to moderate pain such as headache, musculoskeletal discomfort, and dental pain, as well as for the reduction of fever associated with common infections or inflammatory conditions.
How do ibuprofen and paracetamol work together in Lekofen?+
Ibuprofen reduces inflammation by blocking cyclooxygenase enzymes that produce prostaglandins at the site of injury, while paracetamol acts centrally to inhibit prostaglandin synthesis in the brain, providing antipyretic and analgesic effects. The combination offers complementary pain relief through peripheral and central pathways.
What is the usual dose of Lekofen?+
The appropriate dose of Lekofen is determined by the prescribing healthcare professional based on the patient’s age, weight, and clinical condition. Patients should follow the prescriber’s instructions and not exceed the recommended amount.
Is Lekofen safe to use during pregnancy or breastfeeding?+
Safety in pregnancy and lactation has not been fully established. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using Lekofen.
How do I order Lekofen from GNH USA?+
To place an order, submit an enquiry on the Lekofen product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.
How does Lekofen compare with using ibuprofen alone?+
Lekofen combines ibuprofen with paracetamol, offering broader analgesic coverage. While ibuprofen alone provides anti‑inflammatory and analgesic effects, the addition of paracetamol enhances fever reduction and pain relief, often allowing lower doses of each component compared with single‑ingredient therapy.
What are the recommended storage conditions for Lekofen?+
Store Lekofen at ambient temperature, preferably below 25 °C. Keep the tablets in the original container, protect them from moisture, excessive heat and direct sunlight to maintain potency and stability.
How is Lekofen administered?+
Lekofen is taken orally with a full glass of water. It may be taken with or without food, although taking it with food can reduce the likelihood of gastrointestinal discomfort.
What are the most serious risks associated with Lekofen?+
Serious risks include severe allergic reactions (anaphylaxis), liver injury, kidney impairment, and gastrointestinal bleeding or ulceration. Patients should seek immediate medical attention if they experience symptoms such as rash, swelling, jaundice, dark urine, or persistent abdominal pain.
Who should avoid using Lekofen?+
Individuals with known hypersensitivity to ibuprofen, paracetamol, or any excipients, those with severe renal or hepatic impairment, active gastrointestinal ulcers, or who are taking anticoagulants without medical supervision should avoid using Lekofen.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Ibuprofen, Paracetamol
Route
Oral Use
Manufacturer
Sandoz D.O.O.
Origin
EU

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