Lekap

Sildenafil, the active ingredient in Lekap, is a phosphodiesterase type 5 inhibitor presented as an oral tablet for oral use. It treats erectile dysfunction and pulmonary arterial hypertension in adult patients.

GNH USA supplies Lekap as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Sildenafil acts on the nitric‑oxide/cGMP pathway to improve vascular function in specific conditions.

- Erectile dysfunction: enhances the ability to achieve and maintain an erection suitable for sexual activity. - Pulmonary arterial hypertension: lowers pulmonary arterial pressure and improves exercise capacity. - Male sexual dysfunction related to vascular insufficiency: supports satisfactory sexual performance.

Sildenafil may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects: - Headache: mild to moderate pain often resolving within a few hours. - Flushing: warmth and redness of the face or upper chest. - Dyspepsia: indigestion or upset stomach. - Nasal congestion: blocked or runny nose. - Visual disturbances: blurred vision or color tinge. - Back pain: muscular discomfort, typically after several hours.

Serious or Rare Side Effects: - Priapism: prolonged erection lasting more than four hours, requiring urgent medical care. - Sudden hearing loss: abrupt decrease or loss of hearing. - Myocardial infarction: heart attack, especially in patients with cardiovascular disease. - Stroke: cerebrovascular accident presenting with neurological deficits. - Severe hypotension: marked drop in blood pressure causing dizziness or fainting. - Allergic reaction: rash, itching, swelling, or difficulty breathing.

Before initiating therapy, consider the following safety measures.

- Cardiovascular assessment: evaluate for recent heart attack, unstable angina, or severe heart failure. - Nitrate use: avoid concurrent use with any nitrate medication due to risk of profound hypotension. - Visual disorders: discontinue if sudden vision loss or eye pain occurs. - Hearing disorders: monitor for sudden hearing changes and seek medical attention if noted. - Hepatic or renal impairment: dose adjustment may be required in severe dysfunction. - Store at room temperature: keep in the original packaging, protect from moisture and direct sunlight.

Sildenafil can interact with several drug classes; awareness helps prevent adverse events.

Major Interactions (Avoid): - Nitrates: concurrent use can cause dangerous drops in blood pressure. - Guanylate cyclase stimulators (e.g., riociguat): additive vasodilatory effect may lead to severe hypotension. - Alpha‑blockers: combined effect may result in marked blood pressure reduction.

Moderate Interactions (Monitor Closely): - CYP3A4 inhibitors (e.g., erythromycin, ketoconazole): may increase sildenafil plasma levels. - Antihypertensive agents: additive blood pressure‑lowering effect requires monitoring.