Leflon

Leflunomide, the active ingredient in Leflon, is an immunosuppressant presented as an oral formulation for systemic use. It is indicated for the treatment of rheumatoid arthritis and psoriatic arthritis in adult patients, helping to reduce joint inflammation and disease progression.

GNH USA supplies Leflon as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to EU quality standards and provides reliable sourcing for regulated markets. Customers benefit from consistent batch release, comprehensive documentation, and responsive technical support.

Leflunomide is used to manage autoimmune inflammatory disorders, primarily affecting the joints.

Rheumatoid arthritis: reduces signs and symptoms, slows radiographic progression, and improves functional ability. Psoriatic arthritis: alleviates joint pain, skin lesions, and disease activity. Inflammatory arthritis (moderate to severe): helps control disease activity and prevent further joint damage.

Leflunomide may cause a range of adverse reactions, from mild to severe.

Common Side Effects: - Diarrhea: loose stools that may be intermittent. - Nausea: feeling of stomach upset, often mild. - Rash: skin irritation or erythema. - Elevated liver enzymes: mild increases in ALT/AST.

Serious or Rare Side Effects: - Severe liver injury: jaundice, hepatitis, or hepatic failure. - Bone marrow suppression: leukopenia, anemia, or thrombocytopenia. - Interstitial lung disease: cough, dyspnea, or pulmonary infiltrates.

Before initiating therapy, several safety considerations are recommended.

Pregnancy: contraindicated (Category X) due to proven teratogenic risk. Liver function: obtain baseline tests and monitor periodically for hepatotoxicity. Blood counts: regularly assess for leukopenia, anemia, or thrombocytopenia. Infection risk: evaluate for active infections and avoid initiating therapy during uncontrolled infection. Vaccination: do not administer live vaccines while on treatment. Store at ambient temperature: keep below 25 °C, protect from moisture and light in the original container.

Leflunomide can interact with several medicines, requiring careful management.

Major Interactions (Avoid): - Warfarin: may increase anticoagulant effect; monitor INR closely. - Methotrexate: additive hepatotoxicity; frequent liver function tests are required. - Live vaccines: heightened infection risk; avoid concurrent use.

Moderate Interactions (Monitor Closely): - Statins: possible increased risk of myopathy; monitor CK levels. - Azathioprine: enhanced immunosuppression; watch blood counts. - Rituximab: may reduce therapeutic efficacy; monitor disease activity.