Leflon

Leflunomide, the active ingredient in Leflon, is an immunomodulatory agent presented as an oral tablet for oral use. It treats rheumatoid arthritis and psoriatic arthritis in adult patients, helping to reduce inflammation and slow disease progression.

GNH USA supplies Leflon as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Leflunomide is a disease-modifying antirheumatic drug (DMARD) used in autoimmune joint disorders.

- Rheumatoid arthritis: reduces joint inflammation, pain, and slows structural damage. - Psoriatic arthritis: improves skin lesions and joint symptoms, helping to control disease activity.

Leflon may cause a range of adverse reactions, from mild to severe.

Common Side Effects: - Diarrhoea: loose stools occurring intermittently. - Nausea: feeling of stomach upset, sometimes with vomiting. - Headache: mild to moderate pain in the head region. - Hypertension: elevated blood pressure readings.

Serious or Rare Side Effects: - Hepatotoxicity: significant liver enzyme elevations or liver injury. - Severe infection: increased susceptibility to bacterial, viral or fungal infections. - Pulmonary toxicity: interstitial lung disease or pneumonitis, presenting with cough and breathlessness.

Before initiating Leflon, several safety considerations are recommended.

- Liver monitoring: perform baseline and periodic liver function tests. - Blood pressure: monitor regularly, especially in patients with hypertension. - Pregnancy: contraindicated; avoid use in women of child‑bearing potential. - Breastfeeding: not recommended as drug may be excreted in milk. - Infection risk: assess for active infections before starting therapy. Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Leflon can interact with several medicines; awareness of the interaction level is essential.

Major Interactions (Avoid): - Warfarin: increased anticoagulant effect, risk of bleeding. - Teriflunomide: additive toxicity, especially hepatic. - Live vaccines: may cause uncontrolled infection.

Moderate Interactions (Monitor Closely): - Methotrexate: enhanced immunosuppression, monitor blood counts. - Statins: potential for increased muscle toxicity, observe for myalgia.