Lederfoline (Calcium Folinate)

Calcium Folinate, the active ingredient in Lederfoline, is a folate analog presented as an oral dosage form for oral use. It is employed to counteract methotrexate toxicity, support certain chemotherapy regimens, and treat folate deficiency in patients requiring rapid repletion.

GNH USA supplies Lederfoline as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies and clinics worldwide.

Calcium folinate is used in clinical situations that involve folate metabolism disruption or methotrexate exposure.

- Methotrexate toxicity: rescues normal cells from the toxic effects of methotrexate. - Cancer chemotherapy regimens: stabilises intracellular folate pools to enhance the safety of selected chemotherapeutic agents. - Folate deficiency: provides rapid repletion of folate stores when deficiency is clinically significant.

Adverse reactions may occur with calcium folinate administration.

Common Side Effects: - Nausea: mild to moderate upset stomach. - Vomiting: occasional emesis. - Diarrhoea: loose stools. - Rash: mild skin erythema. - Headache: transient cranial discomfort. - Fatigue: general tiredness.

Serious or Rare Side Effects: - Anaphylactic reaction: severe allergic response requiring immediate medical attention. - Stevens‑Johnson syndrome: rare severe skin eruption. - Acute renal failure: sudden loss of kidney function. - Pancytopenia: marked reduction in blood cell lines. - Hepatic dysfunction: elevated liver enzymes or hepatitis. - Severe hypotension: marked drop in blood pressure.

Calcium folinate should be used with attention to specific clinical conditions.

- Renal impairment: monitor renal function and adjust dose if necessary. - Hepatic dysfunction: use cautiously and observe liver enzymes. - Pregnancy: weigh potential benefits against risks; limited data available. - Concurrent methotrexate therapy: ensure appropriate timing to avoid antagonism. - Known hypersensitivity: discontinue immediately if allergic reaction occurs. - Store at ambient temperature: keep below 25°C, retain in original packaging, protect from moisture.

Calcium folinate can modify the activity of several drugs.

Major Interactions (Avoid): - Methotrexate: may reduce therapeutic effect if not co‑administered as a rescue. - Pemetrexed (antifolate): antagonistic interaction diminishing anticancer activity. - High‑dose folic acid supplements: can blunt rescue efficacy.

Moderate Interactions (Monitor Closely): - NSAIDs: may increase risk of renal toxicity when combined. - Trimethoprim: additive folate antagonism requiring monitoring. - 5‑Fluorouracil: dose adjustments may be needed to maintain efficacy.