Lecigon

Levodopa/Carbidopa/Entacapone, the active ingredient in Lecigon, is a combination antiparkinson agent presented as a combination tablet for intestinal use. It treats Parkinson's disease motor symptoms and reduces OFF periods in adult patients.

GNH USA supplies Lecigon as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Lecigon, a combination antiparkinson agent, is indicated for the management of Parkinson's disease.

Parkinson's disease (early stage): improves motor function and reduces rigidity. Parkinson's disease (advanced stage with motor fluctuations): decreases OFF periods and enhances daily activity. Parkinson's disease (adjunct to levodopa therapy): prolongs levodopa effect and stabilizes dopamine levels.

Adverse reactions may occur with Lecigon and should be monitored.

Common Side Effects: - Nausea or vomiting - Dizziness or light‑headedness - Orthostatic hypotension - Insomnia or vivid dreams - Dyskinesia or involuntary movements - Dry mouth or constipation

Serious or Rare Side Effects: - Severe liver injury or hepatitis - Neuroleptic malignant syndrome - Severe hypotension or syncope - Allergic reactions such as rash or angioedema - Agranulocytosis or severe neutropenia - Cardiac arrhythmias

Before initiating therapy, consider the following precautions.

Monitor for dyskinesia: adjust dose if involuntary movements develop. Assess liver function: periodic testing is recommended. Adjust in renal impairment: dose may need modification. Avoid in known hypersensitivity: discontinue if allergic reaction occurs. Use caution in cardiovascular disease: watch for hypotension. Store at ambient temperature: keep in the original pack, protect from moisture and heat.

Lecigon may interact with other medicines; review patient medication lists.

Major Interactions (Avoid): - Non‑selective MAO inhibitors: risk of hypertensive crisis. - Anticholinergic drugs: may diminish antiparkinson effect. - Certain antidepressants (e.g., SSRIs) when combined with MAO‑B inhibitors.

Moderate Interactions (Monitor Closely): - Antihypertensive agents: additive blood pressure lowering. - Antipsychotics: may reduce levodopa efficacy. - Iron or vitamin C supplements: can affect levodopa absorption. - High‑protein meals: may compete with levodopa transport.