Lecigon

Entacapone, the active ingredient in Lecigon, is a Levodopa/Carbidopa/Entacapone combination presented as an oral tablet for intestinal use. It is prescribed to manage Parkinson's disease and to reduce motor fluctuations in patients already receiving levodopa/carbidopa therapy. The formulation combines levodopa, which is converted to dopamine in the brain, with carbidopa to inhibit peripheral metabolism, and entacapone to block catechol‑O‑methyltransferase, thereby enhancing and prolonging dopaminergic stimulation.

GNH USA supplies Lecigon as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Lecigon, a Levodopa/Carbidopa/Entacapone combination, is used in the management of Parkinson's disease and related motor complications. - Parkinson's disease (adjunct therapy to levodopa/carbidopa): improves overall motor control and reduces symptom severity. - Motor fluctuations in Parkinson's disease: decreases OFF time and prolongs ON periods. - Wearing‑off phenomenon in Parkinson's disease: enhances dopaminergic stimulation to smooth daily motor performance.

Common Side Effects: - Nausea: gastrointestinal upset occurring early in therapy. - Orthostatic hypotension: dizziness or light‑headedness upon standing. - Dyskinesia: involuntary movements linked to dopaminergic excess. - Insomnia: difficulty initiating or maintaining sleep.

Serious or Rare Side Effects: - Severe liver injury: elevated transaminases requiring monitoring. - Neuroleptic malignant syndrome: rare but life‑threatening reaction. - Severe diarrhea: may lead to dehydration. - Allergic reactions: rash, pruritus, or anaphylaxis. - Hallucinations: visual or auditory disturbances, especially in older patients.

Patients should be monitored for known risks associated with dopaminergic therapy. - Monitor blood pressure: watch for orthostatic changes. - Assess liver function: entacapone may affect hepatic enzymes. - Evaluate for psychiatric symptoms: hallucinations may occur. - Avoid use in patients with known hypersensitivity to any component. - Store at ambient temperature below 25°C: keep in the original pack, protect from moisture.

Entacapone/Levodopa/Carbidopa may interact with several drug classes.

Major Interactions (Avoid): - MAO‑B inhibitors: increased risk of hypertensive crisis. - Non‑selective MAO inhibitors: severe hypertension. - Anticholinergic drugs: may worsen cognitive side effects.

Moderate Interactions (Monitor Closely): - Antihypertensive agents: additive hypotensive effect. - Antipsychotics: may diminish dopaminergic response.