GNH USA

Europe — EMA

Lecigon

GNH USA supplies Lecigon (Entacapone/Levodopa/Carbidopa), a COMT and DOPA decarboxylase inhibitor for Parkinson's disease. Request a quote for global supply.

Entacapone, Levodopa, Carbidopa Monohydrate

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What is Entacapone, Levodopa, Carbidopa Monohydrate?

Entacapone, Levodopa and Carbidopa, the active ingredients in Lecigon, are a COMT inhibitor; DOPA decarboxylase inhibitor; dopamine precursor presented as a combination tablet for intestinal use. It treats the motor symptoms of Parkinson's disease in adult patients.

GNH USA supplies Lecigon as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Entacapone, Levodopa, Carbidopa Monohydrate used for?

Lecigon is used in the management of Parkinson's disease and related motor complications. - Parkinson's disease: improves overall motor control and reduces rigidity and bradykinesia. - Parkinson's disease with motor fluctuations: shortens OFF periods and prolongs ON time. - Early‑stage Parkinson's disease: enhances the clinical response to levodopa therapy.

What are the side effects of Entacapone, Levodopa, Carbidopa Monohydrate?

Common Side Effects: - Nausea: mild to moderate gastrointestinal upset. - Dizziness: transient light‑headedness, especially on standing. - Headache: occasional tension‑type headache. - Constipation: reduced bowel motility.

Serious or Rare Side Effects: - Severe liver injury: elevated transaminases, jaundice. - Neuroleptic malignant syndrome: high fever, muscle rigidity. - Severe hypotension: sudden drop in blood pressure. - Agranulocytosis: marked reduction in white blood cells. - Anaphylaxis: life‑threatening allergic reaction.

What precautions apply to Entacapone, Levodopa, Carbidopa Monohydrate?

Before initiating therapy, consider the following precautions. - Monitor liver function: obtain baseline tests and repeat periodically. - Assess for dyskinesia: adjust levodopa dose if excessive movements develop. - Avoid use in patients with known hypersensitivity to any component. - Use caution in cardiovascular disease: monitor blood pressure and heart rate. - Store at ambient temperature: keep in the original container, protect from moisture and light.

What does Entacapone, Levodopa, Carbidopa Monohydrate interact with?

Lecigon may interact with several medicines; review the following. Major Interactions (Avoid): - Non‑selective MAO inhibitors: risk of hypertensive crisis. - Anticholinergic agents: may increase anticholinergic burden. - Ipecac syrup: can reduce drug absorption. Moderate Interactions (Monitor Closely): - Other COMT inhibitors: additive inhibition may cause excess levodopa. - Dopamine agonists: heightened risk of dyskinesia. - SSRIs or SNRIs: potential for serotonin syndrome when combined with MAO‑B inhibitors.

Frequently asked questions

What is Lecigon used for?+
Lecigon is a fixed‑dose combination of entacapone, levodopa and carbidopa indicated for the treatment of Parkinson's disease. It helps improve motor symptoms such as tremor, rigidity, and bradykinesia, and is particularly useful in patients who experience wearing‑off periods with levodopa alone.
How does entacapone, levodopa and carbidopa work together?+
Levodopa is a precursor that is converted to dopamine in the brain, restoring deficient neurotransmission. Carbidopa blocks peripheral decarboxylation of levodopa, allowing more to reach the central nervous system. Entacapone inhibits the COMT enzyme, reducing peripheral breakdown of levodopa and extending its duration of action.
What is the usual dose of Lecigon?+
The specific dose and dosing schedule of Lecigon are determined by the prescribing clinician based on the individual patient's disease severity, response to therapy, and tolerability. Patients should follow the prescriber’s instructions and not adjust the dose without medical guidance.
Is Lecigon safe during pregnancy or breastfeeding?+
Safety data for Lecigon in pregnancy and lactation are limited. The product should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant, and this decision must be made by a qualified healthcare professional.
How do I order Lecigon from GNH USA?+
To place an order, submit an enquiry on the Lecigon product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.
How does Lecigon compare with other Parkinson's medications?+
Lecigon combines a COMT inhibitor (entacapone) with levodopa and carbidopa, offering longer and more stable levodopa plasma levels compared with levodopa/carbidopa alone. This can reduce OFF periods and improve motor control, whereas other classes such as dopamine agonists act on different receptors and may have distinct side‑effect profiles.
What are the storage and handling requirements for Lecigon?+
Lecigon tablets should be stored at ambient temperature, below 25 °C, in the original blister pack or container. Protect them from moisture, excessive heat and direct sunlight to maintain product stability throughout its shelf life.
How is Lecigon administered?+
Lecigon is taken orally, usually with food to reduce gastrointestinal irritation. The tablets are swallowed whole with a glass of water. The exact timing relative to meals and other Parkinson's medications should follow the prescribing clinician’s directions.
What are the most serious risks associated with Lecigon?+
Serious adverse events include severe liver injury, neuroleptic malignant syndrome, marked hypotension, agranulocytosis and life‑threatening allergic reactions such as anaphylaxis. Patients should be monitored closely for any signs of these conditions and seek immediate medical attention if they occur.
Who should not use Lecigon?+
Lecigon is contraindicated in individuals with known hypersensitivity to entacapone, levodopa, carbidopa or any excipients in the formulation. It should also be avoided in patients taking non‑selective MAO inhibitors or those with severe hepatic impairment unless specifically advised by a physician.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Entacapone, Levodopa, Carbidopa Monohydrate
Route
Intestinal Use
Manufacturer
Lobsor Pharmaceuticals Ab
Origin
EU

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