GNH USA

Europe — EMA

Lecigon

GNH USA supplies Lecigon (Entacapone/Levodopa/Carbidopa), a combination antiparkinson agent for motor fluctuations in Parkinson's disease. Request a quote.

Entacapone, Levodopa, Carbidopa Monohydrate

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What is Entacapone, Levodopa, Carbidopa Monohydrate?

Entacapone, the active ingredient in Lecigon, is a Combination (MAO‑B inhibitor, DOPA decarboxylase inhibitor, dopamine precursor) presented as an oral tablet for intestinal use. It is prescribed to improve motor fluctuations in patients with Parkinson's disease.

GNH USA supplies Lecigon as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Entacapone, Levodopa, Carbidopa Monohydrate used for?

Lecigon is a combination antiparkinson agent that targets dopaminergic pathways to manage motor complications in Parkinson's disease.

- Parkinson's disease (motor fluctuations): improves ON time and reduces OFF periods. - Parkinson's disease (wearing‑off phenomenon): prolongs the effect of levodopa. - Parkinson's disease (off periods): decreases the frequency and severity of off episodes.

What are the side effects of Entacapone, Levodopa, Carbidopa Monohydrate?

Adverse reactions may occur with Lecigon and should be monitored.

Common Side Effects: - Nausea and vomiting - Dizziness or light‑headedness - Diarrhea or abdominal discomfort - Urine discoloration (brownish) - Dyskinesia (involuntary movements) - Hallucinations or visual disturbances

Serious or Rare Side Effects: - Severe hypotension or syncope - Neuroleptic malignant syndrome - Hepatotoxicity or elevated liver enzymes - Severe allergic reactions (rash, angioedema) - Suicidal thoughts or severe depression - Persistent or worsening dyskinesia

What precautions apply to Entacapone, Levodopa, Carbidopa Monohydrate?

Before initiating Lecigon, clinicians should consider several safety measures.

- Monitor for dyskinesia: adjust therapy if involuntary movements appear. - Assess liver function: entacapone may affect hepatic enzymes. - Avoid abrupt discontinuation: taper to prevent withdrawal effects. - Use caution in cardiovascular disease: risk of orthostatic hypotension. - Contraindicated in narrow‑angle glaucoma: may increase intra‑ocular pressure. - Store at room temperature: keep in the original pack, protect from moisture.

What does Entacapone, Levodopa, Carbidopa Monohydrate interact with?

Lecigon can interact with other medicines; awareness of the interaction level is essential.

Major Interactions (Avoid): - Non‑selective MAO inhibitors: risk of hypertensive crisis. - Antipsychotics (e.g., haloperidol): may diminish antiparkinson effect. - Certain antihypertensives: additive blood‑pressure lowering.

Moderate Interactions (Monitor Closely): - Other dopaminergic agents (e.g., pramipexole): may increase dyskinesia. - Anticholinergics: may affect motor control. - Iron or vitamin C supplements: can reduce levodopa absorption.

Frequently asked questions

What is Lecigon used for?+
Lecigon is a fixed‑dose combination of entacapone, levodopa and carbidopa that is used to improve motor fluctuations in patients with Parkinson's disease. It helps increase the duration of the medication’s beneficial effect and reduces periods when symptoms return.
How does the combination of entacapone, levodopa and carbidopa work?+
Levodopa is converted to dopamine in the brain, restoring deficient neurotransmission. Carbidopa blocks peripheral conversion of levodopa, allowing more to reach the brain. Entacapone inhibits the COMT enzyme, slowing levodopa breakdown and extending its plasma half‑life, which together provide smoother symptom control.
What is the usual dose of Lecigon?+
The dose of Lecigon is individualized. A qualified prescriber determines the appropriate strength, frequency and total daily amount based on the patient’s clinical condition, response to therapy and tolerability.
Is Lecigon safe during pregnancy or breastfeeding?+
Safety of Lecigon in pregnancy or lactation has not been established. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and this decision must be made by the treating physician.
How do I order Lecigon from GNH USA?+
To request Lecigon, submit an enquiry on the product page at gnh-usa.com with the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.
How does Lecigon compare with other Parkinson’s treatments?+
Lecigon combines a COMT inhibitor (entacapone) with levodopa/carbidopa, offering longer levodopa exposure than levodopa/carbidopa alone. Compared with dopamine agonists, it provides a more direct dopamine replacement but may have a higher risk of dyskinesia. Choice depends on individual patient needs and physician assessment.
What are the storage requirements for Lecigon?+
Lecigon tablets should be stored at room temperature, below 25 °C. Keep them in the original packaging, protect from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability.
How is Lecigon administered?+
Lecigon is taken orally, usually with food to reduce gastrointestinal upset. The tablets are swallowed whole with a glass of water. The exact timing and frequency are prescribed by the treating clinician.
What are the most serious risks associated with Lecigon?+
Serious risks include severe hypotension, neuroleptic malignant syndrome, liver toxicity, severe allergic reactions, and worsening psychiatric symptoms such as depression or suicidal thoughts. Patients should be monitored closely for these events, and any concerning signs should prompt immediate medical evaluation.
Who should not use Lecigon?+
Lecigon is contraindicated in patients taking non‑selective MAO inhibitors, those with narrow‑angle glaucoma, or individuals with known hypersensitivity to any component of the product. Caution is also advised for patients with severe cardiovascular disease, liver impairment, or a history of psychiatric disorders.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Entacapone, Levodopa, Carbidopa Monohydrate
Route
Intestinal Use
Manufacturer
Lobsor Pharmaceuticals Ab
Origin
EU

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