Lecalcif

Colecalciferol, the active ingredient in Lecalcif, is a Vitamin D analog presented as a oral dosage form for oral use. It treats vitamin D deficiency and supports bone health in adults and children.

GNH USA supplies Lecalcif as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Lecalcif, a vitamin D analog, is used to address disorders of calcium metabolism and bone mineralization.

- Vitamin D deficiency: restores adequate serum 25‑hydroxyvitamin D levels. - Osteomalacia/rickets prevention: supports normal bone mineralization in at‑risk populations. - Bone health support: helps maintain calcium and phosphate balance for skeletal health.

Common Side Effects: - Nausea: mild stomach upset may occur. - Constipation: occasional bowel slowing. - Headache: transient head discomfort. - Dry mouth: reduced salivation. - Fatigue: feeling of low energy. - Mild hypercalcemia: slight elevation of blood calcium without symptoms.

Serious or Rare Side Effects: - Severe hypercalcemia: can cause vomiting, arrhythmia, and renal impairment. - Hypercalciuria: excess calcium in urine leading to kidney stones. - Allergic reaction: rash, itching, or swelling. - Hypersensitivity anaphylaxis: rare but life‑threatening. - Calcinosis: abnormal calcium deposition in tissues. - Renal failure: in extreme cases of prolonged hypercalcemia.

Before initiating Lecalcif, consider the following precautions: - Baseline assessment: check serum calcium and vitamin D levels. - Renal function: monitor in patients with kidney disease. - Hypercalcemia risk: avoid in individuals with existing high calcium. - Pregnancy and lactation: use only if benefit outweighs risk and under medical advice. - Drug interactions: review concomitant medications that affect calcium metabolism. - Store at ambient temperature: keep below 25°C, retain original packaging, protect from moisture and direct sunlight.

Major Interactions (Avoid): - Thiazide diuretics: may exacerbate hypercalcemia. - High‑dose calcium supplements: increase risk of calcium overload. - Vitamin A excess: synergistic toxicity. - Rifampin: accelerates vitamin D metabolism, reducing efficacy. - Anticonvulsants (e.g., phenobarbital): increase vitamin D catabolism.

Moderate Interactions (Monitor Closely): - Corticosteroids: may impair vitamin D activation. - Loop diuretics: can affect calcium balance. - Digoxin: heightened risk of arrhythmia with hypercalcemia. - Bisphosphonates: concurrent use may alter calcium dynamics. - Cholestyramine: may reduce absorption of vitamin D.