GNH USA

Europe — EMA

Lecalcif (Colecalciferol)

GNH USA supplies Lecalcif (Colecalciferol), a Vitamin D analog for vitamin D deficiency, prevention of osteomalacia/rickets, and bone health support.

Colecalciferol

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What is Colecalciferol?

Colecalciferol, the active ingredient in Lecalcif, is a Vitamin D analog presented as a oral dosage form for oral use. It treats vitamin D deficiency and supports bone health in adults and children.

GNH USA supplies Lecalcif as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Colecalciferol used for?

Lecalcif, a vitamin D analog, is used to address disorders of calcium metabolism and bone mineralization.

- Vitamin D deficiency: restores adequate serum 25‑hydroxyvitamin D levels. - Osteomalacia/rickets prevention: supports normal bone mineralization in at‑risk populations. - Bone health support: helps maintain calcium and phosphate balance for skeletal health.

What are the side effects of Colecalciferol?

Common Side Effects: - Nausea: mild stomach upset may occur. - Constipation: occasional bowel slowing. - Headache: transient head discomfort. - Dry mouth: reduced salivation. - Fatigue: feeling of low energy. - Mild hypercalcemia: slight elevation of blood calcium without symptoms.

Serious or Rare Side Effects: - Severe hypercalcemia: can cause vomiting, arrhythmia, and renal impairment. - Hypercalciuria: excess calcium in urine leading to kidney stones. - Allergic reaction: rash, itching, or swelling. - Hypersensitivity anaphylaxis: rare but life‑threatening. - Calcinosis: abnormal calcium deposition in tissues. - Renal failure: in extreme cases of prolonged hypercalcemia.

What precautions apply to Colecalciferol?

Before initiating Lecalcif, consider the following precautions: - Baseline assessment: check serum calcium and vitamin D levels. - Renal function: monitor in patients with kidney disease. - Hypercalcemia risk: avoid in individuals with existing high calcium. - Pregnancy and lactation: use only if benefit outweighs risk and under medical advice. - Drug interactions: review concomitant medications that affect calcium metabolism. - Store at ambient temperature: keep below 25°C, retain original packaging, protect from moisture and direct sunlight.

What does Colecalciferol interact with?

Major Interactions (Avoid): - Thiazide diuretics: may exacerbate hypercalcemia. - High‑dose calcium supplements: increase risk of calcium overload. - Vitamin A excess: synergistic toxicity. - Rifampin: accelerates vitamin D metabolism, reducing efficacy. - Anticonvulsants (e.g., phenobarbital): increase vitamin D catabolism.

Moderate Interactions (Monitor Closely): - Corticosteroids: may impair vitamin D activation. - Loop diuretics: can affect calcium balance. - Digoxin: heightened risk of arrhythmia with hypercalcemia. - Bisphosphonates: concurrent use may alter calcium dynamics. - Cholestyramine: may reduce absorption of vitamin D.

Frequently asked questions

What is Lecalcif used for?+
Lecalcif contains colecalciferol, a form of vitamin D3, and is used to treat vitamin D deficiency, prevent osteomalacia or rickets, and support overall bone health by ensuring adequate calcium and phosphate absorption.
How does colecalciferol work?+
After ingestion, colecalciferol is converted in the liver to 25‑hydroxyvitamin D and then in the kidney to the active hormone 1,25‑dihydroxyvitamin D. This active form binds the nuclear vitamin D receptor, stimulating production of calcium‑binding proteins that increase intestinal calcium and phosphate uptake.
What is the usual dose of Lecalcif?+
The prescribed dose of Lecalcif is individualized by a healthcare professional based on the patient’s serum vitamin D level, age, weight, and clinical condition. Dosage may range from low maintenance to higher therapeutic amounts, and the prescriber determines the appropriate regimen.
Is Lecalcif safe during pregnancy or breastfeeding?+
Safety data for colecalciferol in pregnancy and lactation are limited. It should only be used when the potential benefit outweighs any possible risk, and under medical supervision. Pregnant or nursing individuals should consult their healthcare provider before starting Lecalcif.
How do I order Lecalcif from GNH USA?+
To place an order, submit an enquiry on the product page at gnh-usa.com specifying the required quantity. GNH USA works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.
How does Lecalcif compare with other vitamin D supplements?+
Lecalcif provides colecalciferol, the natural form of vitamin D3, which is generally preferred over vitamin D2 (ergocalciferol) due to higher potency and longer duration of action. Compared with prescription calcitriol, colecalciferol requires metabolic activation, offering a safer profile for routine supplementation.
What are the storage requirements for Lecalcif?+
Store Lecalcif at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability throughout its shelf life.
How is Lecalcif administered?+
Lecalcif is taken orally, usually with or without food, as directed by a healthcare professional. The tablet or capsule should be swallowed whole with a glass of water. Patients should follow the prescriber’s instructions regarding timing and frequency.
What are the most serious risks to watch for with Lecalcif?+
The most serious risk is hypercalcemia, which can cause nausea, vomiting, weakness, and cardiac arrhythmias. Severe hypercalcemia may lead to kidney stones or renal impairment. Prompt monitoring of serum calcium and vitamin D levels helps mitigate these risks.
Who should not use Lecalcif?+
Individuals with known hypersensitivity to colecalciferol or any excipients, patients with hypercalcemia, severe renal disease, or granulomatous disorders such as sarcoidosis should avoid Lecalcif unless a physician determines it is safe. Consultation with a healthcare provider is essential before initiating therapy.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Colecalciferol
Route
Oral Use
Manufacturer
Rafarm Sa.
Origin
EU

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