Le-Vof

Levofloxacin, the active ingredient in Le-Vof, is a fluoroquinolone presented as a intravenous solution for intravenous use. It treats a range of bacterial infections in adult patients, including pneumonia, urinary and intra‑abdominal infections.

GNH USA supplies Le-Vof as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Levofloxacin is a broad‑spectrum antibacterial indicated for several serious infections. - Community‑acquired pneumonia: achieves clinical cure and microbiological eradication. - Hospital‑acquired pneumonia: effective in treating resistant Gram‑negative pathogens. - Complicated urinary tract infections: resolves infection and prevents recurrence. - Complicated intra‑abdominal infections: provides rapid bacterial clearance. - Skin and soft tissue infections: reduces lesion size and bacterial load. - Acute bacterial sinusitis: improves symptoms and clears the causative organism.

Levofloxacin may cause a variety of adverse reactions, ranging from mild to severe.

Common Side Effects: - Nausea: mild to moderate upset stomach. - Diarrhea: loose stools, sometimes watery. - Headache: transient cranial discomfort. - Dizziness: sensation of light‑headedness or unsteadiness. - Rash: erythematous skin eruptions. - Elevated liver enzymes: transient increase in hepatic transaminases.

Serious or Rare Side Effects: - Tendon rupture: especially Achilles tendon, often linked to sudden activity. - QT interval prolongation: may predispose to cardiac arrhythmias. - Clostridioides difficile infection: severe colitis with watery diarrhea. - Severe allergic reactions: anaphylaxis, angioedema, or Stevens‑Johnson syndrome. - Seizures: particularly in patients with CNS disorders. - Hepatic failure: rare but potentially life‑threatening liver injury.

Levofloxacin requires careful assessment of patient‑specific factors before use. - Renal impairment: dose adjustment may be necessary based on creatinine clearance. - History of tendon disorders: avoid use in patients with recent tendon injury or surgery. - QT prolongation risk: monitor ECG in patients with cardiac disease or electrolyte abnormalities. - Pregnancy and lactation: prescribe only if potential benefits outweigh risks. - Concomitant medications: review for interactions that may increase toxicity or reduce efficacy. - Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Levofloxacin can affect the pharmacokinetics or pharmacodynamics of several drugs.

Major Interactions (Avoid): - Antacids containing magnesium or aluminum: markedly reduce levofloxacin absorption. - Warfarin: may increase INR and bleeding risk. - Cyclosporine: elevated serum levels can lead to nephrotoxicity. - Theophylline: increased risk of seizures and cardiac arrhythmias. - Other fluoroquinolones: additive toxicity, especially tendon and CNS effects.

Moderate Interactions (Monitor Closely): - NSAIDs: heightened risk of CNS stimulation and seizures. - Corticosteroids: increased chance of tendon rupture. - Diabetic agents (e.g., insulin, sulfonylureas): potential for hypoglycemia. - QT‑prolonging drugs (e.g., macrolides, antiarrhythmics): monitor cardiac rhythm. - Oral contraceptives: possible reduction in contraceptive efficacy.