Lattulosio Teva

Lactulose, the active ingredient in Lattulosio, is an osmotic laxative presented as an oral solution for oral use. It is used to treat constipation and to prevent or treat hepatic encephalopathy in patients with liver disease.

GNH USA supplies Lattulosio as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Lactulose acts as an osmotic agent to relieve bowel stasis and to lower blood ammonia levels in liver disease.

- Constipation: softens stools and promotes bowel movements. - Hepatic encephalopathy: reduces ammonia absorption, helping to improve mental status. - Pediatric constipation: provides a safe, non‑stimulant option for children with functional constipation.

Lactulose may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects: - Abdominal cramping: discomfort due to increased intestinal activity. - Flatulence: excess gas production from bacterial fermentation. - Diarrhea: loose stools from osmotic water retention. - Nausea: mild stomach upset. - Bloating: sensation of fullness. - Thirst: increased fluid loss.

Serious or Rare Side Effects: - Severe dehydration: excessive fluid loss requiring medical attention. - Electrolyte imbalance: particularly low potassium or sodium levels. - Allergic reaction: rash, itching, or swelling. - Hepatic decompensation: worsening liver function in susceptible patients.

When prescribing lactulose, clinicians should consider several safety aspects.

- Assess renal function: impaired kidneys may affect drug clearance. - Monitor electrolytes: risk of hyponatremia or hypokalemia. - Use caution in diabetes: monitor blood glucose as lactulose can affect carbohydrate metabolism. - Avoid in intestinal obstruction: risk of perforation. - Store at ambient temperature: keep in the original container, protect from moisture.

Lactulose can interact with other medicines, altering efficacy or safety.

Major Interactions (Avoid): - Antibiotics (e.g., rifaximin): may reduce lactulose's ammonia‑lowering effect. - Other laxatives (e.g., senna): additive laxative action can cause severe diarrhea.

Moderate Interactions (Monitor Closely): - Antidiabetic agents: monitor glucose as lactulose may affect glycemic control. - Mineral supplements (e.g., calcium, magnesium): may interfere with absorption. - Diuretics: watch for electrolyte disturbances. - Oral hypoglycemics: adjust dose if needed. - Proton pump inhibitors: may alter gut flora and lactulose metabolism.