Lastin

Azelastine Hydrochloride, the active ingredient in Lastin, is a second‑generation antihistamine presented as a nasal spray for intranasal use. It treats allergic rhinitis, including seasonal and perennial forms, by relieving nasal congestion, itching, sneezing and rhinorrhea in adults and children.

GNH USA supplies Lastin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Lastin, a second‑generation antihistamine, is used to manage conditions within the allergic rhinitis disease family.

- Allergic rhinitis: reduces nasal congestion, itching, sneezing and runny nose. - Seasonal allergic rhinitis: alleviates symptoms triggered by pollen or outdoor allergens. - Perennial allergic rhinitis: provides relief from year‑round indoor allergen‑induced nasal symptoms.

Azelastine nasal spray may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects: - Nasal irritation or burning sensation - Bitter or unpleasant taste - Headache - Drowsiness or mild sedation - Dry mouth - Cough or throat clearing

Serious or Rare Side Effects: - Anaphylactic reaction or severe allergy - Angioedema of the face or throat - Bronchospasm or worsening asthma - Severe dizziness or vertigo - Visual disturbances - Persistent or profuse nosebleeds

When using Lastin, consider the following precautions to ensure safe and effective therapy.

- Pregnancy: consult a healthcare provider before use as safety data are limited. - Breastfeeding: discuss potential infant exposure with a physician. - Concomitant CNS depressants: monitor for additive drowsiness. - Pre‑existing asthma or COPD: use with caution and observe respiratory status. - Surgery or anesthesia: inform the anesthesiologist of antihistamine use. - Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Azelastine may interact with other medicines; awareness of interaction severity helps guide clinical decisions.

Major Interactions (Avoid): - Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may raise azelastine concentrations, increasing side‑effect risk.

Moderate Interactions (Monitor Closely): - Alcohol: can enhance drowsiness and sedation. - CNS depressants (benzodiazepines, other antihistamines): may increase sedation. - Other intranasal decongestants: may cause additive nasal irritation. - Anticholinergic drugs: may worsen dry mouth.