GNH USA

Europe — EMA

Lasokun

GNH USA supplies Lasokun (Ranolazine), an antianginal agent for chronic stable angina, improving myocardial oxygen use.

Ranolazine

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What is Ranolazine?

Ranolazine, the active ingredient in Lasokun, is an antianginal agent presented as an oral tablet for oral use. It is indicated for the treatment of chronic stable angina in adult patients, helping to reduce the frequency of angina attacks, improve exercise tolerance, and enhance myocardial oxygen efficiency.

GNH USA supplies Lasokun as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable global distribution.

What is Ranolazine used for?

Ranolazine is used in the management of chronic stable angina, a condition characterized by reduced myocardial blood flow.

Chronic stable angina: reduces frequency of angina episodes and improves exercise capacity. Angina pectoris: alleviates chest pain associated with myocardial ischemia. Myocardial ischemia: enhances myocardial oxygen utilization and relaxation.

What are the side effects of Ranolazine?

Ranolazine may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects: - Dizziness - Headache - Nausea

Serious or Rare Side Effects: - QT interval prolongation - Severe allergic reactions (e.g., Stevens‑Johnson syndrome) - Hepatic injury

What precautions apply to Ranolazine?

When prescribing Lasokun, clinicians should consider several safety measures.

Renal impairment: adjust dose or monitor renal function. Hepatic impairment: use with caution and monitor liver enzymes. QT prolongation risk: avoid in patients with known prolonged QT interval. Concomitant QT‑prolonging drugs: avoid combined use. Pregnancy: safety not established; use only if benefit outweighs risk. Store at ambient temperature: keep in original packaging, protect from moisture.

What does Ranolazine interact with?

Ranolazine can interact with other medicines, requiring careful management.

Major Interactions (Avoid): - Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): may increase ranolazine levels. - Strong CYP3A4 inducers (e.g., rifampin, carbamazepine): may reduce efficacy. - Other QT‑prolonging agents (e.g., sotalol, quinidine): increase risk of arrhythmia.

Moderate Interactions (Monitor Closely): - Digoxin: may increase serum digoxin concentrations. - Antihypertensive agents: monitor blood pressure as additive effects possible. - Other antianginal drugs (e.g., nitrates, beta‑blockers): assess for combined therapeutic effect.

Frequently asked questions

What is Lasokun used for?+
Lasokun contains ranolazine and is prescribed for the management of chronic stable angina, a condition where reduced blood flow to the heart muscle causes chest pain during physical activity or stress. It helps to lessen the frequency of angina attacks and improve patients’ ability to exercise.
How does ranolazine work?+
Ranolazine works by selectively inhibiting the late inward sodium current in cardiac cells. This reduces intracellular sodium and secondary calcium overload, which improves myocardial relaxation and makes the heart muscle use oxygen more efficiently during periods of limited blood supply, thereby reducing angina symptoms.
What is the usual dose of Lasokun?+
The dosage of Lasokun is determined by the prescribing physician based on the individual’s clinical condition, renal function, and response to therapy. The prescriber will select the appropriate strength and titration schedule, and patients should follow the prescribed regimen exactly as instructed.
Is Lasokun safe during pregnancy or breastfeeding?+
The safety of ranolazine in pregnancy and lactation has not been established. It should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision should be made in consultation with a qualified healthcare professional.
How do I order Lasokun from GNH USA?+
To request Lasokun, submit an enquiry on the product page at gnh-usa.com specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.
How does Lasokun compare with other antianginal drugs?+
Unlike beta‑blockers or calcium‑channel blockers, ranolazine does not significantly affect heart rate or blood pressure. Its unique mechanism of reducing intracellular sodium makes it a useful adjunct for patients who remain symptomatic despite standard therapy, offering an alternative when conventional agents are insufficient or not tolerated.
How should Lasokun be stored and handled?+
Lasokun tablets should be stored at ambient temperature, below 25 °C, in the original container to protect them from moisture and light. Keep the medication out of reach of children and do not use it after the expiry date printed on the packaging.
How is Lasokun administered?+
Lasokun is taken orally, usually with or without food, as directed by the prescribing clinician. The tablets should be swallowed whole with a glass of water and not crushed or chewed unless specifically instructed by a healthcare provider.
What are the most serious risks associated with Lasokun?+
The most serious adverse effects include QT interval prolongation, which can lead to potentially life‑threatening arrhythmias, severe allergic reactions such as Stevens‑Johnson syndrome, and hepatic injury. Patients should be monitored for cardiac rhythm changes and liver function abnormalities during therapy.
Who should not use Lasokun?+
Lasokun is contraindicated in patients with known prolonged QT interval, those taking other QT‑prolonging medications, and individuals with severe hepatic impairment. It should also be avoided in patients with a history of serious hypersensitivity to ranolazine or any of the tablet’s excipients.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Ranolazine
Route
Oral Use
Manufacturer
Zentiva, K.S.
Origin
EU

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