Larofen

Ibuprofen, the active ingredient in Larofen, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an oral tablet for oral use. It provides analgesic, antipyretic and anti‑inflammatory effects for the relief of mild to moderate pain, fever and inflammatory conditions in adults and children when appropriate.

GNH USA supplies Larofen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Ibuprofen is used to manage pain and inflammation across several common clinical conditions. - Headache: reduces pain and associated discomfort. - Musculoskeletal pain: alleviates pain and improves mobility in conditions such as sprains, strains and arthritis. - Fever: lowers elevated body temperature in febrile states.

Ibuprofen may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects: - Gastrointestinal discomfort: nausea, dyspepsia or abdominal pain. - Headache: mild to moderate intensity. - Dizziness or vertigo. - Skin rash or mild itching.

Serious or Rare Side Effects: - Gastrointestinal ulceration or bleeding. - Renal impairment or acute kidney injury. - Severe hypersensitivity reactions such as Stevens‑Johnson syndrome. - Cardiovascular events including myocardial infarction or stroke.

When using ibuprofen, several safety considerations should be observed to minimise risk. - Assess renal function: avoid use in patients with severe renal impairment without medical supervision. - Monitor gastrointestinal risk: use with caution in individuals with a history of ulcers or bleeding. - Evaluate cardiovascular status: limit use in patients with uncontrolled hypertension or known heart disease. - Use during pregnancy: consult a healthcare professional; ibuprofen is generally avoided in the third trimester. - Drug interactions: review concomitant medications for potential interactions before initiating therapy. - Store at ambient temperature: keep below 25 °C in the original container, protect from moisture and direct sunlight.

Ibuprofen can interact with other medicines, altering their effectiveness or safety profile.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased risk of serious bleeding. - High‑dose aspirin: heightened gastrointestinal toxicity. - Selective COX‑2 inhibitors: additive renal and cardiovascular adverse effects.

Moderate Interactions (Monitor Closely): - ACE inhibitors or ARBs: may reduce antihypertensive effect and impair renal function. - Diuretics: potential for decreased renal perfusion. - Lithium: ibuprofen can raise serum lithium levels. - Methotrexate: may increase methotrexate toxicity at high doses.