GNH USA

Europe — EMA

Lariam

GNH USA supplies Lariam (Mefloquine Hydrochloride), a antimalarial for prevention and treatment of malaria infection. Request a quote for global supply.

Mefloquine Hydrochloride

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What is Mefloquine Hydrochloride?

Mefloquine hydrochloride, the active ingredient in Lariam, is an antimalarial (quinoline) presented as a tablet for oral use. It treats and prevents malaria infection in travelers and residents of endemic areas.

GNH USA supplies Lariam as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Mefloquine Hydrochloride used for?

Lariam is an antimalarial that acts on the Plasmodium parasite to prevent and treat infection.

Prevention of malaria infection: provides chemoprophylaxis for individuals traveling to or residing in endemic regions. Acute Plasmodium falciparum malaria: effective treatment of uncomplicated infections. Acute Plasmodium vivax malaria: effective treatment of uncomplicated infections.

What are the side effects of Mefloquine Hydrochloride?

Common Side Effects: - Nausea and vomiting - Dizziness or vertigo - Insomnia or vivid dreams - Headache - Visual disturbances - Gastrointestinal discomfort Serious or Rare Side Effects: - Neuropsychiatric reactions such as depression, anxiety, or psychosis - Severe allergic reactions including anaphylaxis - Cardiac arrhythmias or QT prolongation - Hepatic toxicity or elevated liver enzymes - Seizures or convulsions

What precautions apply to Mefloquine Hydrochloride?

Precautions should be observed when prescribing Lariam.

Pregnancy: safety not established; avoid unless benefits outweigh risks. Breastfeeding: unknown; consider potential exposure to infant. History of psychiatric disorders: use with caution due to neuropsychiatric risk. Cardiac disease: monitor for arrhythmias and QT interval changes. Drug interactions: review concomitant medications for potential effects. Store at ambient temperature: keep below 25°C, in original packaging, protected from moisture.

What does Mefloquine Hydrochloride interact with?

Lariam may interact with several medicines.

Major Interactions (Avoid): - Strong CYP3A4 inhibitors (e.g., ketoconazole): increase mefloquine levels. - Anticonvulsants (e.g., carbamazepine, phenytoin): reduce efficacy. - QT‑prolonging agents: heighten risk of cardiac arrhythmia. Moderate Interactions (Monitor Closely): - Antacids: may affect absorption. - Rifampin: may lower plasma concentrations. - Cimetidine: may increase mefloquine exposure.

Frequently asked questions

What is Lariam used for?+
Lariam (mefloquine hydrochloride) is an oral antimalarial indicated for chemoprophylaxis and for treatment of acute malaria caused by susceptible Plasmodium species. It is prescribed for travelers, military personnel, and residents in endemic regions.
How does mefloquine work?+
Mefloquine interferes with the parasite’s heme detoxification pathway and disrupts membrane function, leading to accumulation of toxic heme and parasite death. It targets the intra‑erythrocytic stage of Plasmodium.
What is the usual dose of Lariam?+
The dosing regimen is determined by the prescribing clinician based on indication, patient weight, and regional resistance patterns. Typical prophylactic schedules start one to two weeks before exposure and continue for four weeks after leaving the endemic area, while therapeutic regimens are individualized.
Is Lariam safe in pregnancy or breastfeeding?+
Safety data in pregnancy and lactation are limited. The drug is generally avoided during pregnancy unless the benefit outweighs potential risk, and breastfeeding mothers should consult a healthcare professional before use.
How do I order Lariam from GNH USA?+
To place an order, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.
How does Lariam compare with the main alternative antimalarial?+
Compared with alternatives such as atovaquone‑proguanil or doxycycline, mefloquine offers a weekly dosing schedule for prophylaxis, which can improve adherence, but it has a higher incidence of neuro‑psychiatric side effects. Choice depends on patient tolerance, resistance patterns and travel duration.
What are the storage requirements for Lariam?+
Lariam tablets should be stored at ambient temperature, below 25 °C, in the original blister pack or container, protected from moisture and direct sunlight. Do not store in a refrigerator or freezer.
How is Lariam administered?+
Lariam is taken orally with a full glass of water, preferably with food to reduce gastrointestinal upset. For prophylaxis, tablets are usually taken once weekly; for treatment, the schedule is prescribed by a qualified healthcare provider.
What are the most serious risks to watch for with Lariam?+
The most serious adverse reactions include neuro‑psychiatric events such as depression, anxiety, psychosis, and severe allergic reactions like anaphylaxis. Cardiac arrhythmias and hepatic toxicity have also been reported; patients should seek immediate medical attention if these occur.
Who should not use Lariam?+
Lariam is contraindicated in individuals with a known hypersensitivity to mefloquine or other quinoline antimalarials, patients with a history of severe psychiatric disorders, and those with significant cardiac conduction abnormalities. It should also be avoided in pregnant women unless no safer alternative is available.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Mefloquine Hydrochloride
Route
Oral Use
Manufacturer
Cheplapharm Arzneimittel Gmbh
Origin
EU

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