Largactil

Chlorpromazine Hydrochloride, the active ingredient in Largactil, is a phenothiazine presented as an injectable solution for intramuscular or intravenous use. It is employed in the management of schizophrenia, acute psychosis and severe agitation, primarily in adult patients requiring rapid control of symptoms.

GNH USA supplies Largactil as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Largactil, a phenothiazine antipsychotic, is used to treat disorders involving dopaminergic overactivity. - Schizophrenia: reduces psychotic symptoms such as delusions, hallucinations and thought disorder. - Acute psychosis: provides rapid symptom control during severe episodes. - Severe agitation: calms extreme restlessness and aggression in psychiatric emergencies.

Adverse reactions may vary in frequency and severity.

Common Side Effects: - Drowsiness: feeling unusually sleepy or fatigued. - Dry mouth: reduced salivation leading to discomfort. - Constipation: slowed gastrointestinal motility. - Orthostatic hypotension: dizziness upon standing. - Weight gain: increased appetite and body weight. - Blurred vision: temporary visual disturbances.

Serious or Rare Side Effects: - Extrapyramidal symptoms: muscle rigidity, tremor, or abnormal movements. - Neuroleptic malignant syndrome: high fever, muscle rigidity, autonomic instability. - Tardive dyskinesia: persistent involuntary facial movements. - Severe hypotension: sudden drop in blood pressure. - Agranulocytosis: markedly reduced white blood cell count. - Cardiac arrhythmias: irregular heart rhythms.

Before initiating therapy, consider patient‑specific factors and monitor for adverse events. - Cardiac assessment: evaluate for pre‑existing heart disease or conduction abnormalities. - Metabolic monitoring: watch for weight gain, glucose intolerance and lipid changes. - CNS depression: avoid concurrent sedatives that may enhance drowsiness. - Elderly patients: start with lower doses and monitor for falls. - Pregnancy and lactation: use only if benefits outweigh potential risks. - Store at ambient temperature: keep in original container, protect from moisture and light.

Chlorpromazine may interact with several drug classes, altering efficacy or safety.

Major Interactions (Avoid): - CNS depressants (e.g., benzodiazepines, opioids): risk of profound sedation and respiratory depression. - Antihypertensives (e.g., alpha‑blockers): additive hypotensive effect. - QT‑prolonging agents (e.g., certain antiarrhythmics): increased risk of cardiac arrhythmias.

Moderate Interactions (Monitor Closely): - Anticholinergic drugs (e.g., antihistamines): heightened anticholinergic burden. - CYP2D6 inhibitors (e.g., fluoxetine): may raise chlorpromazine plasma levels. - Lithium: potential for neurotoxic effects.