Largactil

Chlorpromazine, the active ingredient in Largactil, is a phenothiazine presented as an oral tablet for oral use. It is employed to manage psychotic disorders, bipolar mania, severe nausea, and to provide pre‑operative sedation. GNH USA supplies Largactil as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Chlorpromazine acts on dopamine and other neurotransmitter pathways to treat a range of psychiatric and gastrointestinal conditions. - Schizophrenia: reduces hallucinations, delusions and thought disorder. - Acute psychotic disorders: alleviates severe agitation and psychotic symptoms. - Manic episodes of bipolar disorder: stabilises mood and diminishes manic energy. - Severe nausea and vomiting: controls refractory emesis when other agents fail. - Preoperative sedation: provides calming and anti‑emetic effects before surgery.

Adverse reactions can vary from mild to life‑threatening and should be monitored during therapy.

Common Side Effects: - Sedation: drowsiness or fatigue. - Dry mouth: reduced salivary flow. - Constipation: slowed gastrointestinal transit. - Blurred vision: due to anticholinergic activity. - Weight gain: increased appetite. - Orthostatic hypotension: dizziness on standing.

Serious or Rare Side Effects: - Neuroleptic malignant syndrome: high fever, muscle rigidity, autonomic instability. - Tardive dyskinesia: involuntary, repetitive movements. - Agranulocytosis: severe reduction in white blood cells. - Severe hypotension: marked drop in blood pressure. - Seizures: especially in predisposed individuals.

Chlorpromazine requires careful assessment before and during treatment. - Cardiac monitoring: patients with pre‑existing heart disease should be observed for arrhythmias. - CNS depression: avoid alcohol and other sedatives that may enhance drowsiness. - Anticholinergic load: monitor for urinary retention, glaucoma or constipation. - Metabolic effects: watch for weight gain and lipid changes. - Pregnancy and lactation: use only if benefits outweigh potential risks. - Store at ambient temperature: keep below 25 °C, in the original container, protected from moisture and light.

Chlorpromazine can interact with several drug classes, altering efficacy or safety.

Major Interactions (Avoid): - Monoamine oxidase inhibitors (MAOIs): risk of hypertensive crisis. - CNS depressants (e.g., benzodiazepines, opioids): additive sedation and respiratory depression. - Anticholinergic agents: heightened anticholinergic side effects.

Moderate Interactions (Monitor Closely): - Antihypertensives: may potentiate hypotensive effects. - Lithium: increased risk of neurotoxicity. - Antidiabetic drugs: may mask hypoglycemia symptoms.