Lanoxin

Digoxin, the active ingredient in Lanoxin, is a cardiac glycoside presented as an oral tablet for oral use. It treats heart failure and certain atrial arrhythmias in adult patients. GNH USA supplies Lanoxin as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Lanoxin is a cardiac glycoside that acts on the heart muscle and the electrical conduction system. - Heart failure: improves cardiac output and reduces symptoms of fluid overload. - Atrial fibrillation: slows atrioventricular nodal conduction to control ventricular rate. - Atrial flutter: provides rate control by reducing AV‑node conduction.

Common Side Effects: - Nausea: mild to moderate stomach upset. - Vomiting: occasional emesis, especially after dose changes. - Diarrhea: loose stools may occur. - Fatigue: feeling of tiredness or weakness. - Blurred vision: visual disturbances such as halos. - Headache: mild headache reported.

Serious or Rare Side Effects: - Arrhythmias: ventricular tachycardia or fibrillation. - Severe bradycardia: markedly slow heart rate. - Heart block: advanced AV block requiring pacing. - Hyperkalemia: elevated serum potassium levels. - Visual disturbances: yellow‑green halos or color vision changes. - Allergic reactions: rash, itching, or anaphylaxis.

When using Lanoxin, consider the following precautions: - Renal impairment: adjust dose and monitor serum digoxin levels. - Electrolyte disturbances: correct hypokalemia or hyperkalemia before therapy. - Concomitant AV block: avoid use without a functioning pacemaker. - Pregnancy: use only if benefits outweigh potential risks (Category C). - Elderly patients: start with lower doses and monitor closely. - Store at ambient temperature below 25°C: keep in the original pack, protect from moisture.

Digoxin interacts with several medicines that can alter its plasma concentration or cardiac effects. Major Interactions (Avoid): - Amiodarone: markedly increases digoxin levels. - Quinidine: raises digoxin concentrations. - Verapamil: enhances digoxin effect and risk of toxicity. - Diltiazem: may increase serum digoxin. - Erythromycin and other macrolide antibiotics: elevate digoxin levels.

Moderate Interactions (Monitor Closely): - Thiazide diuretics: can cause hypokalemia, increasing toxicity risk. - ACE inhibitors: may potentiate digoxin's effects. - NSAIDs: may reduce renal clearance of digoxin. - Beta‑blockers: additive bradycardic effect. - Calcium channel blockers (non‑diltiazem): may require monitoring of heart rate.