Lanoxin

Digoxin, the active ingredient in Lanoxin, is a cardiac glycoside presented as an oral tablet for oral use. It treats heart failure and certain arrhythmias such as atrial fibrillation and atrial flutter in adult patients. GNH USA supplies Lanoxin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Lanoxin (digoxin) acts on the cardiac conduction system and myocardial contractility to manage several cardiovascular conditions. - Heart failure: improves symptoms and reduces hospitalizations by increasing cardiac output. - Atrial fibrillation: helps control ventricular rate by slowing atrioventricular conduction. - Atrial flutter: assists in rate control and may aid conversion to sinus rhythm.

Adverse reactions may range from mild to life‑threatening and should be monitored during therapy.

Common Side Effects: - Nausea or vomiting - Diarrhea - Fatigue or weakness - Blurred vision or color disturbances - Dizziness or headache - Loss of appetite

Serious or Rare Side Effects: - Life‑threatening arrhythmias (e.g., ventricular tachycardia) - Severe bradycardia or heart block - Hyperkalemia - Allergic skin reactions (rash, pruritus) - Visual disturbances such as yellow‑green halos - Confusion or hallucinations

Use of digoxin requires careful assessment of patient‑specific factors and monitoring. - Renal impairment: adjust dose and monitor serum digoxin levels. - Electrolyte disturbances: correct potassium, magnesium, and calcium abnormalities before initiating therapy. - Thyroid disease: use cautiously in hyper‑ or hypothyroidism. - Pregnancy: category C; discuss potential risks and benefits with the prescriber. - Elderly patients: increased sensitivity; start with lower doses and monitor closely. - Store at below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Digoxin interacts with several medicines that can alter its plasma concentration or cardiac effects.

Major Interactions (Avoid): - Amiodarone: markedly increases digoxin levels. - Quinidine: raises digoxin concentration and risk of toxicity. - Verapamil or diltiazem: potentiate digoxin’s effects on AV conduction. - Spironalactone: may increase serum digoxin. - Certain macrolide antibiotics (e.g., erythromycin): elevate digoxin levels.

Moderate Interactions (Monitor Closely): - Thiazide diuretics: can cause electrolyte shifts affecting digoxin. - ACE inhibitors or ARBs: may enhance digoxin’s therapeutic effect. - NSAIDs: may reduce renal clearance of digoxin. - Thyroid hormone replacement: may alter digoxin requirements. - Antacids containing aluminum or magnesium: may affect absorption.