Lanoxin

Digoxin, the active ingredient in Lanoxin, is a cardiac glycoside presented as an oral tablet for oral use. It is used to improve cardiac contractility and control ventricular rate in patients with heart failure and atrial fibrillation. The drug exerts its effect by inhibiting the Na⁺/K⁺‑ATPase pump, leading to increased intracellular calcium and stronger myocardial contractions.

GNH USA supplies Lanoxin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. Our distribution network ensures consistent quality and regulatory compliance across EU and global markets.

Lanoxin (digoxin) is indicated for conditions affecting cardiac function and rhythm.

- Heart failure: improves cardiac output and reduces symptoms of congestion. - Atrial fibrillation: slows atrioventricular nodal conduction to control ventricular rate. - Atrial flutter: assists in rate control when other agents are unsuitable.

Digoxin may cause a range of adverse reactions, varying from mild to potentially life‑threatening.

Common Side Effects: - Nausea: mild gastrointestinal upset. - Fatigue: reduced energy and weakness. - Visual disturbances: blurred or yellow‑green vision.

Serious or Rare Side Effects: - Cardiac arrhythmias: potentially fatal rhythm disturbances. - Severe bradycardia: dangerously low heart rate. - Hyperkalemia: elevated blood potassium levels.

When prescribing digoxin, clinicians should observe several safety measures to minimize toxicity. - Dose adjustment: tailor dose in renal impairment or elderly patients. - Serum level monitoring: check digoxin concentration regularly. - Electrolyte balance: correct hypokalemia, hypomagnesemia, and hypercalcemia before therapy. - Drug interactions: review concomitant medications that affect digoxin clearance. - Pregnancy and lactation: use only if benefit outweighs risk; category C. - Store at ambient temperature: keep tablets in original container, protect from moisture and light.

Digoxin interacts with several medicines; awareness of the interaction level guides clinical decisions.

Major Interactions (Avoid): - Amiodarone: markedly increases digoxin levels, risk of toxicity. - Quinidine: raises digoxin concentration, may cause arrhythmias. - Verapamil: enhances digoxin effect, leading to bradycardia.

Moderate Interactions (Monitor Closely): - Diuretics (e.g., furosemide): may cause electrolyte disturbances that predispose to toxicity. - ACE inhibitors: can increase serum digoxin by reducing clearance. - Beta‑blockers: additive effect on heart rate and AV nodal conduction.