Lanoxin

Digoxin, the active ingredient in Lanoxin, is a cardiac glycoside presented as an injectable solution for intravenous use. It treats heart failure and certain atrial arrhythmias, such as atrial fibrillation and atrial flutter, in adult patients.

GNH USA supplies Lanoxin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Digoxin is used in the management of cardiac conditions that involve reduced contractility or abnormal atrial rhythms.

Heart failure: improves cardiac output and reduces symptoms of congestion. Atrial fibrillation: slows atrioventricular nodal conduction to control ventricular rate. Atrial flutter: provides rate control by decreasing AV nodal conduction.

Common Side Effects: - Nausea or vomiting - Diarrhea - Blurred or yellow‑green vision - Fatigue or headache

Serious or Rare Side Effects: - Life‑threatening arrhythmias (e.g., ventricular tachycardia) - Severe bradycardia or heart block - Allergic reactions such as rash or anaphylaxis - Hyperkalemia, especially in renal impairment

Before initiating therapy, clinicians should consider several safety measures. - Serum level monitoring: check digoxin concentration to avoid toxicity. - Renal function assessment: adjust use in patients with impaired clearance. - Electrolyte review: correct hypokalemia, hypomagnesemia, or hypercalcemia. - Elderly patients: start with lower doses and monitor closely. - Contraindicated in patients with known ventricular arrhythmias. - Store at 2‑8°C: keep refrigerated, protect from light, do not freeze or shake.

Digoxin interacts with many medicines that can alter its plasma concentration or cardiac effects.

Major Interactions (Avoid): - Amiodarone: markedly increases digoxin levels. - Quinidine: raises serum digoxin and may precipitate toxicity. - Verapamil: enhances digoxin concentration and slows AV conduction. - Spironolactone: can elevate digoxin levels, increasing toxicity risk.

Moderate Interactions (Monitor Closely): - Loop or thiazide diuretics: may cause electrolyte shifts that predispose to toxicity. - ACE inhibitors or ARBs: can increase digoxin concentration indirectly. - NSAIDs: may reduce renal clearance of digoxin. - Diltiazem: modestly raises digoxin levels. - Thyroid hormone therapy: may potentiate digoxin's cardiac effects.