Lanoxin

Digoxin, the active ingredient in Lanoxin, is a cardiac glycoside presented as an injectable solution for intravenous use. It is employed to improve cardiac contractility in heart failure and to achieve rate control in atrial fibrillation, mainly in adult patients.

GNH USA supplies Lanoxin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation for cross‑border distribution, ensuring product integrity throughout the supply chain.

Digoxin is a cardiac glycoside used in the management of heart failure and atrial arrhythmias.

Heart failure: improves ventricular contractility and reduces symptoms of fluid overload. Atrial fibrillation (rate control): slows atrioventricular conduction to maintain an appropriate ventricular rate. Atrial flutter (rate control): reduces ventricular response by decreasing AV nodal conduction.

Common Side Effects: - Nausea: mild to moderate gastrointestinal upset. - Vomiting: occasional emesis, especially with rapid infusion. - Diarrhea: loose stools may occur. - Blurred vision: transient visual disturbances, such as yellow‑green halos.

Serious or Rare Side Effects: - Life‑threatening arrhythmias: ventricular tachycardia or fibrillation. - Severe bradycardia: markedly reduced heart rate. - Heart block: advanced AV conduction delay. - Allergic skin reactions: rash, urticaria, or angioedema.

Before initiating therapy, consider the following precautions: - Renal function: adjust dose in patients with impaired clearance. - Electrolytes: monitor potassium and magnesium levels to avoid toxicity. - Cardiac monitoring: obtain baseline and periodic ECGs for arrhythmia detection. - Pregnancy: use only if the potential benefit justifies the potential risk (Category C). - Breastfeeding: assess risk versus benefit, as digoxin is excreted in milk. Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Digoxin has several clinically important drug interactions.

Major Interactions (Avoid): - Amiodarone: markedly increases digoxin serum concentrations. - Quinidine: can precipitate digoxin toxicity. - Dronedarone: may raise digoxin levels and risk of arrhythmias.

Moderate Interactions (Monitor Closely): - Beta‑blockers: additive effects on heart rate and AV conduction. - Diuretics causing hypokalemia: low potassium enhances digoxin toxicity. - ACE inhibitors or ARBs: may increase serum digoxin through reduced renal clearance.