Lanoxin

Digoxin, the active ingredient in Lanoxin, is a cardiac glycoside presented as an injectable solution for intravenous administration. It is used to manage atrial fibrillation, atrial flutter, and congestive heart failure in adult patients.

GNH USA supplies Lanoxin as a licensed, GDP‑compliant international pharmaceutical product, providing reliable access to hospitals, pharmacies and clinics worldwide. The product conforms to EU market standards and is manufactured under strict quality controls.

Digoxin is employed in cardiac conditions that involve abnormal rhythm or reduced contractility.

- Atrial fibrillation: helps control ventricular rate and may restore sinus rhythm. - Atrial flutter: reduces rapid atrial activity and improves ventricular response. - Congestive heart failure: increases myocardial contractility, enhancing cardiac output and relieving symptoms.

Common Side Effects: - Nausea: mild to moderate gastrointestinal upset. - Vomiting: occasional episodes after dosing. - Diarrhea: loose stools may occur. - Fatigue: feeling of tiredness or weakness. - Blurred vision: visual disturbances, often transient. - Dizziness: light‑headed sensation.

Serious or Rare Side Effects: - Cardiac arrhythmias: ventricular tachycardia or fibrillation. - Severe bradycardia: markedly slowed heart rate. - Heart block: advanced atrioventricular conduction delay. - Hyperkalemia: elevated serum potassium levels. - Allergic reactions: rash, itching, or anaphylaxis. - Visual halos: yellow‑green colored halos around lights.

Before initiating therapy, consider the following safety measures.

- Monitor serum digoxin levels: ensure therapeutic range and avoid toxicity. - Assess renal function: dosage adjustment may be required in impairment. - Check electrolytes: especially potassium, as hypokalemia increases risk of toxicity. - Use caution in elderly patients: increased sensitivity to cardiac effects. - Avoid in patients with ventricular arrhythmias or high‑grade AV block. - Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Digoxin interacts with several medicines that can alter its concentration or cardiac effects.

Major Interactions (Avoid): - Amiodarone: markedly increases digoxin levels. - Quinidine: raises serum digoxin and may cause toxicity. - Verapamil: enhances digoxin concentration and slows AV conduction. - Beta‑blockers (e.g., propranolol): may potentiate bradycardia. - Loop diuretics (e.g., furosemide): cause hypokalemia, increasing toxicity risk.

Moderate Interactions (Monitor Closely): - Calcium channel blockers (diltiazem): may modestly raise digoxin levels. - ACE inhibitors: can affect renal handling of digoxin. - NSAIDs: may reduce renal clearance, elevating serum concentrations.