Lanoxin 250

Digoxin, the active ingredient in Lanoxin 250, is a cardiac glycoside presented as a 0.25 mg tablet for oral use. It treats heart failure and atrial fibrillation in adult patients by increasing myocardial contractility and moderating atrioventricular conduction. GNH USA supplies Lanoxin 250 as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to Good Distribution Practice and provides full regulatory documentation for global markets.

Digoxin is used in cardiovascular conditions that involve impaired cardiac output or abnormal atrial rhythm.

- Heart failure: improves symptoms, exercise tolerance and cardiac output. - Atrial fibrillation: helps control ventricular rate in patients with rapid atrial response. - Atrial flutter: assists in rate control when other therapies are insufficient.

Common Side Effects: - Nausea or vomiting - Diarrhea - Loss of appetite - Fatigue - Blurred or yellow‑green vision - Dizziness

Serious or Rare Side Effects: - Life‑threatening arrhythmias (e.g., ventricular tachycardia) - Severe bradycardia or heart block - Hyperkalemia - Allergic skin reactions (rash, pruritus) - Visual disturbances with halos or color changes - Confusion or hallucinations

Before initiating therapy, clinicians should consider patient‑specific factors and monitor for toxicity. - Renal impairment: adjust dose and monitor serum levels. - Electrolyte disturbances: correct potassium, magnesium and calcium abnormalities. - Thyroid disease: use with caution as digoxin sensitivity may change. - Pregnancy (Category C): weigh maternal benefit against fetal risk. - Elderly patients: start with lower dose due to increased sensitivity. - Store at ambient temperature: keep below 25 °C, in the original container, protected from moisture.

Digoxin has several clinically important drug interactions that require attention.

Major Interactions (Avoid): - Amiodarone: markedly increases digoxin concentrations. - Quinidine: can cause digoxin toxicity. - Verapamil or diltiazem: potentiate digoxin effects and raise serum levels.

Moderate Interactions (Monitor Closely): - Loop or thiazide diuretics: may cause electrolyte shifts that predispose to toxicity. - ACE inhibitors or ARBs: can enhance digoxin's effect on the heart. - NSAIDs: may reduce renal clearance of digoxin. - Antacids containing aluminum or magnesium: may decrease digoxin absorption.