GNH USA

Europe — EMA

Lamprene (Clofazimine)

GNH USA supplies Lamprene (Clofazimine), a phenazine dye for multibacillary leprosy and Mycobacterium avium complex infections.

Clofazimine

Request sourcing

1
Pack/s

What is Clofazimine?

Clofazimine, the active ingredient in Lamprene, is a phenazine dye presented as a 100 mg oral capsule for oral use. It is indicated for the treatment of multibacillary leprosy and for adjunct therapy of Mycobacterium avium complex infections, particularly in patients with compromised immune systems.

GNH USA supplies Lamprene as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, providing quality‑assured products to a global network of healthcare institutions and adhering to EU GMP standards, and supports reliable supply chains across Europe, Asia and the Americas.

What is Clofazimine used for?

Clofazimine is employed in the management of mycobacterial infections, primarily targeting leprosy and related conditions.

- Multibacillary leprosy: reduces bacterial load and contributes to clinical remission. - Mycobacterium avium complex infections: used as adjunct therapy to improve outcomes in immunocompromised patients. - Leprosy reaction (erythema nodosum leprosum): helps modulate inflammatory response and alleviate symptoms.

What are the side effects of Clofazimine?

Clofazimine may cause a range of adverse reactions, varying in frequency and severity.

Common Side Effects: - Skin discoloration: brown to black pigmentation of the skin. - Gastrointestinal upset: nausea, abdominal pain, or dyspepsia. - Pruritus: itching, sometimes with rash. - Mild headache.

Serious or Rare Side Effects: - Photosensitivity: increased risk of sunburn. - Severe cutaneous reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis. - Hepatotoxicity: elevated liver enzymes or liver injury. - Hematologic abnormalities: neutropenia, eosinophilia, or anemia.

What precautions apply to Clofazimine?

When prescribing Clofazimine, clinicians should consider several precautionary measures to ensure safe use. - Pregnancy: safety not established; avoid unless benefits outweigh risks. - Breastfeeding: unknown; monitor infant for discoloration. - Renal impairment: use with caution; dose adjustment may be required. - Hepatic impairment: monitor liver function tests regularly. - Skin discoloration: counsel patients about reversible and permanent pigmentation changes. - Store at ambient temperature: keep below 25 °C in the original container, protect from moisture and light.

What does Clofazimine interact with?

Clofazimine can interact with other medicines, affecting its efficacy or safety.

Major Interactions (Avoid): - Rifampicin: induces metabolism, reducing Clofazimine levels. - Protease inhibitor antiretrovirals: may increase toxicity. - Warfarin: potential additive anticoagulant effect.

Moderate Interactions (Monitor Closely): - Macrolide antibiotics (e.g., azithromycin): may increase QT prolongation risk. - Antifungal azoles (e.g., ketoconazole): may affect Clofazimine clearance. - Diabetes medications: monitor blood glucose as Clofazimine may affect glucose control.

Frequently asked questions

What is Lamprene used for?+
Lamprene contains Clofazimine and is prescribed for the treatment of multibacillary leprosy and as adjunct therapy for Mycobacterium avium complex infections, especially in patients with weakened immune systems. It may also be used to manage leprosy reactions such as erythema nodosum leprosum.
How does Clofazimine work?+
Clofazimine intercalates into bacterial DNA, disrupting replication, and generates reactive oxygen species through redox cycling that damage mycobacterial cell membranes. It also accumulates in macrophages, providing sustained activity against dormant bacilli, and exerts anti‑inflammatory effects that help control leprosy reactions.
What is the usual dose of Lamprene?+
The specific dose of Lamprene is determined by the prescribing clinician based on the patient’s condition, weight, and treatment guidelines. Dosage regimens may vary, and adjustments are made for renal or hepatic impairment as needed.
Is Lamprene safe during pregnancy or breastfeeding?+
Safety of Clofazimine in pregnancy and lactation has not been established. It should only be used during pregnancy if the potential benefit justifies the potential risk to the fetus, and breastfeeding is generally discouraged unless the infant is closely monitored for skin discoloration or other effects.
How do I order Lamprene from GNH USA?+
To order Lamprene, submit an enquiry on the product page at gnh-usa.com specifying the required quantity. GNH USA supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.
How does Lamprene compare with the main alternative drug or class?+
The primary alternative for leprosy treatment is the multidrug regimen that includes dapsone and rifampicin. Compared with dapsone, Clofazimine has a distinct mechanism involving DNA intercalation and reactive oxygen species generation, and it offers additional anti‑inflammatory benefits, though it is more associated with skin pigmentation changes.
How should Lamprene be stored and handled?+
Lamprene capsules should be stored at ambient temperature, preferably below 25 °C. Keep them in the original packaging to protect from moisture and light. Do not store in a refrigerator or freezer, and keep out of reach of children.
How is Lamprene administered?+
Lamprene is taken orally as a 100 mg capsule. It can be swallowed whole with a glass of water, with or without food, as directed by the prescriber. Consistency in timing helps maintain steady drug levels.
What are the most serious risks to watch for while taking Lamprene?+
Serious risks include severe skin reactions such as Stevens‑Johnson syndrome or toxic epidermal necrolysis, significant hepatotoxicity, and hematologic abnormalities like neutropenia or eosinophilia. Patients should report any unexplained rash, yellowing of the skin or eyes, or unusual bruising promptly.
Who should not use Lamprene?+
Lamprene should be avoided in individuals with known hypersensitivity to Clofazimine or any phenazine dyes. Patients with severe liver disease or uncontrolled hepatic impairment should not use it without close monitoring. Caution is also advised for those with pre‑existing cardiac conditions that predispose to QT prolongation.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
Send a sourcing enquiry for this product →

Product details

Drug
Clofazimine
Route
Oral Use
Manufacturer
Novartis Pharma S.A.S.
Origin
EU