GNH USA

Europe — EMA

Lamivudine/Zidovudine Viatris

GNH USA supplies Lamivudine/Zidovudine Viatris (Lamivudine/Zidovudine), a nucleoside reverse transcriptase inhibitor for HIV-1 infection treatment.

Zidovudine, Lamivudine

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What is Zidovudine, Lamivudine?

Lamivudine and Zidovudine, the active ingredients in Lamivudine/Zidovudine Viatris, are nucleoside reverse transcriptase inhibitors presented as an oral tablet for oral use. They treat HIV-1 infection in adults and adolescents.

GNH USA supplies Lamivudine/Zidovudine Viatris as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Zidovudine, Lamivudine used for?

Lamivudine/Zidovudine is a nucleoside reverse transcriptase inhibitor used in the management of HIV infection.

- HIV‑1 infection (adults): reduces plasma HIV RNA levels and improves immune function. - HIV‑1 infection (adolescents): helps achieve viral suppression as part of combination antiretroviral therapy. - Prevention of mother‑to‑child transmission: lowers the risk of vertical transmission when used with other antiretrovirals during pregnancy.

What are the side effects of Zidovudine, Lamivudine?

Adverse reactions may occur with Lamivudine/Zidovudine therapy.

Common Side Effects: - Nausea: mild to moderate gastrointestinal upset. - Headache: transient cranial discomfort. - Fatigue: generalised tiredness. - Anemia: reduction in red blood cell count. - Neutropenia: lowered neutrophil levels. - Diarrhoea: loose stools.

Serious or Rare Side Effects: - Lactic acidosis: severe metabolic disturbance. - Hepatomegaly with steatosis: liver enlargement with fat accumulation. - Severe neutropenia: profound drop in neutrophils. - Hypersensitivity reactions: rash, fever, or Stevens‑Johnson syndrome. - Bone‑marrow suppression: pancytopenia. - Pancreatitis: inflammation of the pancreas.

What precautions apply to Zidovudine, Lamivudine?

Before initiating therapy, clinicians should consider several safety measures.

- Monitor blood counts: perform regular CBC to detect anemia or neutropenia. - Assess liver function: check transaminases before and during treatment. - Avoid in patients with known hypersensitivity: discontinue if rash or allergic signs develop. - Use caution with concomitant myelosuppressive agents: increased risk of bone‑marrow suppression. - Pregnancy considerations: evaluate risk/benefit under medical supervision. - Store at ambient temperature: keep below 25°C, retain original packaging, protect from moisture.

What does Zidovudine, Lamivudine interact with?

Lamivudine/Zidovudine may interact with other medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid): - Didanosine co‑administration: heightened risk of severe peripheral neuropathy and pancreatitis. - Stavudine combination: increased mitochondrial toxicity. - Other myelosuppressive drugs: potential for profound bone‑marrow suppression.

Moderate Interactions (Monitor Closely): - Trimethoprim‑sulfamethoxazole: may amplify hematologic toxicity. - Lamotrigine: possible reduction of lamotrigine plasma levels. - Alcohol use: may exacerbate liver toxicity.

Frequently asked questions

What is Lamivudine/Zidovudine used for?+
Lamivudine/Zidovudine is prescribed as part of combination antiretroviral therapy to treat HIV‑1 infection in adults and adolescents. It helps lower viral load, restore immune function, and can be used to reduce the risk of mother‑to‑child transmission when administered during pregnancy.
How does Lamivudine/Zidovudine work?+
Both lamivudine and zidovudine are nucleoside analogues that, after intracellular phosphorylation, mimic natural nucleosides. When incorporated into viral DNA by HIV reverse transcriptase, they cause premature chain termination, blocking viral replication and reducing the amount of virus in the bloodstream.
What is the usual dose of Lamivudine/Zidovudine?+
The specific dose and dosing schedule are determined by the treating physician based on the patient’s clinical condition, weight, renal function, and other medications. Healthcare providers follow established guidelines and adjust the regimen as needed for optimal viral suppression.
Is Lamivudine/Zidovudine safe during pregnancy or breastfeeding?+
Safety in pregnancy and lactation must be evaluated by a qualified clinician. The drug may be used when the benefits to the mother outweigh potential risks to the fetus, and breastfeeding decisions should consider the infant’s exposure through milk and the mother’s health status.
How do I order Lamivudine/Zidovudine from GNH USA?+
To place an order, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.
How does Lamivudine/Zidovudine compare with other antiretroviral options?+
Lamivudine/Zidovudine is a fixed‑dose NRTI combination offering convenience compared with separate tablets. Compared with newer agents such as tenofovir/emtricitabine, it may have a different safety profile, including a higher risk of anemia and neutropenia, but remains an effective component of many established regimens.
What are the storage and handling requirements for Lamivudine/Zidovudine?+
The product should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in the original blister or container, protect them from moisture and direct sunlight, and ensure the packaging remains sealed until use.
How is Lamivudine/Zidovudine administered?+
Lamivudine/Zidovudine is taken orally, usually as a tablet, with or without food as directed by the prescriber. The medication is part of a broader antiretroviral regimen and should be taken consistently at the same times each day to maintain therapeutic levels.
What are the most serious risks associated with Lamivudine/Zidovudine?+
Serious adverse events include severe anemia, neutropenia, lactic acidosis, hepatomegaly with steatosis, and hypersensitivity reactions such as Stevens‑Johnson syndrome. Patients should be monitored regularly for hematologic and hepatic abnormalities, and any signs of severe toxicity require immediate medical attention.
Who should not use Lamivudine/Zidovudine?+
Individuals with known hypersensitivity to lamivudine, zidovudine, or any component of the formulation should avoid the drug. Caution is also advised for patients with pre‑existing severe anemia, bone‑marrow suppression, or significant liver disease, and use should be guided by a healthcare professional.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Zidovudine, Lamivudine
Route
Oral Use
Manufacturer
Viatris Sante
Origin
EU

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