GNH USA

Europe — EMA

Lamivudine Teva Pharma B.V

GNH USA supplies Lamivudine Teva Pharma B.V (Lamivudine), a nucleoside reverse transcriptase inhibitor for HIV infection and chronic hepatitis B.

Lamivudine

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What is Lamivudine?

Lamivudine, the active ingredient in Lamivudine Teva Pharma B.V, is a nucleoside reverse transcriptase inhibitor presented as an oral tablet for oral use. It is used to treat human immunodeficiency virus (HIV) infection and chronic hepatitis B infection in adult patients. GNH USA supplies Lamivudine Teva Pharma B.V as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Lamivudine used for?

Lamivudine is an antiretroviral medication that targets viral replication in specific infections. - Human immunodeficiency virus (HIV) infection: reduces viral load when combined with other antiretrovirals. - Chronic hepatitis B infection: suppresses hepatitis B virus DNA replication. - Prevention of mother‑to‑child transmission of HIV: lowers the risk of neonatal infection when administered to pregnant women.

What are the side effects of Lamivudine?

Lamivudine may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects: - Nausea: mild to moderate stomach upset. - Headache: transient cranial discomfort. - Fatigue: general tiredness. - Diarrhea: loose stools.

Serious or Rare Side Effects: - Lactic acidosis: buildup of lactic acid, requiring immediate medical attention. - Severe hepatomegaly with steatosis: significant liver enlargement with fatty changes. - Pancreatitis: inflammation of the pancreas. - Severe skin reactions: such as Stevens‑Johnson syndrome. - Hypersensitivity: including rash, fever, and eosinophilia. - Neutropenia: marked reduction in neutrophil count.

What precautions apply to Lamivudine?

Before initiating lamivudine therapy, several safety considerations should be reviewed. - Renal function: assess and adjust dose in severe impairment. - Hepatic disease: monitor liver enzymes regularly. - Pregnancy: risk category unknown; use only if benefits outweigh potential risks. - Concomitant medications: review for possible interactions that may affect efficacy or toxicity. - Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

What does Lamivudine interact with?

Lamivudine can interact with other medicines, altering its safety or effectiveness.

Major Interactions (Avoid): - Didanosine: increased risk of pancreatitis. - Stavudine: heightened mitochondrial toxicity. - Zidovudine: additive bone‑marrow suppression.

Moderate Interactions (Monitor Closely): - Nevirapine: monitor liver function tests. - Efavirenz: observe for central nervous system effects. - Ribavirin: watch for enhanced anemia.

Frequently asked questions

What conditions is Lamivudine used to treat?+
Lamivudine is prescribed for the treatment of human immunodeficiency virus (HIV) infection, often as part of combination antiretroviral therapy, and for chronic hepatitis B infection to suppress viral replication. It is also used to reduce the risk of mother‑to‑child transmission of HIV when given to pregnant women.
How does Lamivudine work in the body?+
After oral administration, lamivudine is taken up by cells and phosphorylated to its active triphosphate form. This metabolite mimics natural nucleosides and is incorporated by viral reverse transcriptase, causing premature termination of the viral DNA chain and thereby inhibiting replication of HIV and hepatitis B virus.
What is the usual dose of Lamivudine?+
The specific dose of lamivudine is determined by the prescribing healthcare professional based on the patient’s condition, weight, renal function, and other clinical factors. Patients should follow the dosage instructions provided by their prescriber and not adjust the dose on their own.
Is Lamivudine safe to use during pregnancy or breastfeeding?+
The safety of lamivudine in pregnancy and lactation has not been definitively established. It may be prescribed if the potential benefits to the mother outweigh any possible risks to the fetus or infant. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss the risks and benefits with their healthcare provider.
How do I order Lamivudine from GNH USA?+
To place an order, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity of Lamivudine Teva Pharma B.V. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.
How does Lamivudine compare with other antiretroviral drugs?+
Lamivudine belongs to the nucleoside reverse transcriptase inhibitor (NRTI) class, offering a favorable safety profile and convenient once‑daily dosing when combined with other agents. Compared with some older NRTIs, it has lower mitochondrial toxicity and fewer metabolic side effects, making it a common component of modern combination regimens.
What are the recommended storage conditions for Lamivudine?+
Lamivudine tablets should be stored at room temperature, below 25 °C, in the original packaging to protect them from moisture and light. Do not store in areas with high humidity or extreme temperatures, and keep out of reach of children.
How is Lamivudine administered?+
Lamivudine is taken orally, usually with or without food, as a tablet that is swallowed whole with water. The exact administration schedule—once daily or divided doses—depends on the prescribing regimen and should be followed as directed by the healthcare professional.
What are the most serious risks associated with Lamivudine?+
Serious adverse events, although rare, include lactic acidosis, severe hepatomegaly with steatosis, pancreatitis, severe skin reactions such as Stevens‑Johnson syndrome, hypersensitivity reactions, and significant neutropenia. Patients should seek immediate medical attention if they experience symptoms such as unexplained fatigue, abdominal pain, rapid breathing, or skin rash.
Who should not use Lamivudine?+
Lamivudine is contraindicated in patients with known hypersensitivity to the drug or any of its excipients. Caution is also advised for individuals with severe renal impairment, active liver disease, or those taking medications that have major interaction potential, unless close monitoring is possible.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Lamivudine
Route
Oral Use
Manufacturer
Teva B.V
Origin
EU

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