GNH USA

Europe — EMA

Lamivudina + Zidovudina Accord (Zidovudine, Lamivudine)

GNH USA supplies Lamivudina + Zidovudina Accord (Lamivudine/Zidovudine), a nucleoside reverse transcriptase inhibitor for HIV infection.

Zidovudine, Lamivudine

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What is Zidovudine, Lamivudine?

Lamivudine/Zidovudine, the active ingredient in Lamivudina + Zidovudina Accord, is a nucleoside reverse transcriptase inhibitor presented as an oral dosage form for oral use. It is indicated for the treatment of Human Immunodeficiency Virus (HIV) infection in combination with other antiretroviral agents. GNH USA supplies Lamivudina + Zidovudina Accord as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Zidovudine, Lamivudine used for?

Lamivudina + Zidovudina Accord is a nucleoside reverse transcriptase inhibitor used in antiretroviral therapy for HIV infection. - HIV‑1 infection (adults): suppresses viral replication and improves immune function. - HIV‑1 infection (children): forms part of pediatric combination regimens to control disease progression. - Prevention of mother‑to‑child transmission: reduces the risk of vertical HIV transmission when used during pregnancy and delivery.

What are the side effects of Zidovudine, Lamivudine?

Adverse reactions may occur with Lamivudina + Zidovudina Accord.

Common Side Effects: - Nausea: mild to moderate gastrointestinal upset. - Headache: transient cranial discomfort. - Fatigue: generalised tiredness. - Anemia: reduced red blood cell count. - Neutropenia: lowered neutrophil levels. - Diarrhoea: loose stools.

Serious or Rare Side Effects: - Lactic acidosis: severe metabolic disturbance. - Hepatic steatosis: fatty liver disease. - Bone marrow suppression: pancytopenia risk. - Hypersensitivity reactions: rash, fever, eosinophilia. - Pancreatitis: inflammation of the pancreas. - Severe anemia: profound reduction in hemoglobin.

What precautions apply to Zidovudine, Lamivudine?

When prescribing Lamivudina + Zidovudina Accord, consider the following precautions. - Monitor blood counts: regular CBC to detect anemia or neutropenia. - Assess liver function: periodic LFTs for hepatic toxicity. - Evaluate renal function: dose adjustment may be needed in impairment. - Avoid in known hypersensitivity: discontinue if allergic reaction occurs. - Use caution in pregnancy: benefits must outweigh potential risks. - Store at ambient temperature: keep in original packaging, protect from moisture.

What does Zidovudine, Lamivudine interact with?

Lamivudina + Zidovudine may interact with other medicines.

Major Interactions (Avoid): - Didanosine: increased risk of pancreatitis. - Stavudine: heightened mitochondrial toxicity. - Ribavirin: enhanced hematologic toxicity.

Moderate Interactions (Monitor Closely): - Trimethoprim‑sulfamethoxazole: additive bone‑marrow suppression. - NSAIDs: potential renal toxicity. - Alcohol: may exacerbate lactic acidosis risk.

Frequently asked questions

What is Lamivudina + Zidovudina Accord used for?+
Lamivudina + Zidovudina Accord is used as part of combination antiretroviral therapy to treat Human Immunodeficiency Virus (HIV) infection in adults and children, and to help prevent mother‑to‑child transmission of HIV when administered during pregnancy.
How does lamivudine/zidovudine work?+
Both lamivudine and zidovudine are nucleoside analogues that are phosphorylated inside cells to active triphosphate forms. These active metabolites compete with natural nucleosides for incorporation into viral DNA by reverse transcriptase, causing premature chain termination and blocking HIV replication.
What is the usual dose of Lamivudina + Zidovudina Accord?+
The dosage of Lamivudina + Zidovudina Accord is determined by the prescribing healthcare professional based on the patient’s age, weight, renal function, and the overall antiretroviral regimen. Patients should follow the exact dosing instructions provided by their clinician.
Is Lamivudina + Zidovudina safe in pregnancy or breastfeeding?+
Safety in pregnancy and lactation has not been fully established. The drug may be used during pregnancy only when the potential benefits justify the potential risks to the fetus, and breastfeeding decisions should be made in consultation with a healthcare provider.
How do I order Lamivudina + Zidovudina from GNH USA?+
To place an order, submit an enquiry on the product page at gnh-usa.com with the required quantity. GNH USA supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.
How does Lamivudina + Zidovudina compare with other antiretroviral options?+
Lamivudine and zidovudine belong to the nucleoside reverse transcriptase inhibitor class, offering a well‑characterised safety profile and extensive clinical experience. Compared with newer agents, they may have more frequent hematologic side effects but remain effective components of many established combination regimens.
What are the storage and handling requirements for this product?+
Lamivudina + Zidovudina Accord should be stored at ambient temperature, below 25 °C, in its original packaging to protect from moisture and light. Keep the product out of reach of children and avoid storing in humid or excessively hot environments.
How is Lamivudina + Zidovudina administered?+
The medication is taken orally, usually as tablets or capsules, with or without food as directed by the prescriber. Patients should swallow the dosage form whole and not crush or chew it unless specifically instructed.
What are the most serious risks associated with this therapy?+
Serious risks include lactic acidosis, severe hepatic steatosis, bone‑marrow suppression leading to pancytopenia, and hypersensitivity reactions such as rash or fever. Patients should be monitored regularly for these conditions and seek immediate medical attention if symptoms develop.
Who should not use Lamivudina + Zidovudina?+
Individuals with known hypersensitivity to lamivudine, zidovudine, or any excipients in the formulation should avoid this medication. It is also contraindicated in patients with severe bone‑marrow failure or uncontrolled liver disease, and caution is advised in pregnant or breastfeeding women.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Zidovudine, Lamivudine
Route
Oral Use
Manufacturer
Accord Healthcare S.L.U.
Origin
EU

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