GNH USA

Europe — EMA

Lamivudina Accord

GNH USA supplies Lamivudina Accord (Lamivudine), a nucleoside reverse transcriptase inhibitor indicated for HIV‑1 infection and chronic hepatitis B

Lamivudine

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What is Lamivudine?

Lamivudine, the active ingredient in Lamivudina Accord, is a nucleoside reverse transcriptase inhibitor presented as an oral tablet for oral use. It is indicated for the treatment of HIV‑1 infection and chronic hepatitis B infection in adult patients. The tablet is formulated for systemic absorption and is commonly incorporated into combination antiretroviral regimens.

GNH USA supplies Lamivudina Accord as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Lamivudine used for?

Lamivudina Accord (lamivudine) is employed in the management of viral infections that rely on reverse transcriptase, primarily HIV‑1 and chronic hepatitis B.

HIV‑1 infection: reduces plasma viral load, increases CD4+ T‑cell counts, and improves clinical outcomes when used as part of combination antiretroviral therapy. Chronic hepatitis B infection: suppresses HBV DNA replication, leads to normalization of liver enzymes, and reduces the risk of cirrhosis and hepatocellular carcinoma. HBV/HIV coinfection: provides dual antiviral activity, allowing a single tablet regimen that simplifies treatment and enhances adherence for patients infected with both viruses.

What are the side effects of Lamivudine?

Lamivudina Accord may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects: - Nausea - Headache - Fatigue

Serious or Rare Side Effects: - Lactic acidosis - Severe hepatomegaly with steatosis - Stevens‑Johnson syndrome or toxic epidermal necrolysis

What precautions apply to Lamivudine?

Before initiating therapy, clinicians should consider several safety measures. - Monitor liver function: obtain baseline and periodic liver‑function tests. - Assess renal function: dose adjustment may be required in renal impairment. - Screen for hepatitis B flare: monitor HBV DNA levels during treatment. - Avoid in patients with known hypersensitivity to lamivudine. - Store at room temperature: keep in the original container, protect from moisture.

What does Lamivudine interact with?

Lamivudina Accord can interact with other medicines, requiring careful management.

Major Interactions (Avoid): - Didanosine: increased risk of pancreatitis. - Stavudine: heightened mitochondrial toxicity. - Rifampicin: reduces lamivudine plasma concentrations.

Moderate Interactions (Monitor Closely): - Tenofovir: additive renal toxicity. - Efavirenz (NNRTI): may alter lamivudine levels. - Alcohol: may exacerbate liver injury.

Frequently asked questions

What is Lamivudina Accord used for?+
Lamivudina Accord contains lamivudine, which is used to treat HIV‑1 infection and chronic hepatitis B infection in adults. It may be prescribed as part of combination antiretroviral therapy for HIV or as monotherapy for hepatitis B, depending on the clinical situation.
How does lamivudine work?+
Lamivudine is a nucleoside analogue that is converted inside cells to its active triphosphate form. This active metabolite competes with natural nucleotides for incorporation into viral DNA by reverse transcriptase, causing premature chain termination and preventing viral replication.
What is the usual dose of lamivudine?+
The appropriate dose of lamivudine is determined by the prescribing healthcare professional based on the specific indication, patient weight, renal function, and other clinical factors. Dosage regimens may differ between HIV and hepatitis B treatment, and the prescriber will provide individualized instructions.
Is lamivudine safe in pregnancy or breastfeeding?+
Safety data for lamivudine in pregnancy and lactation are limited, and the product is classified as having an unknown pregnancy category. Use is only recommended when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and it should be discussed with a qualified clinician.
How do I order Lamivudina Accord from GNH USA?+
To order Lamivudina Accord, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA supplies hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials before providing pricing, availability, shipping details and any necessary import documentation.
How does lamivudine compare with the main alternative drug or class?+
Lamivudine belongs to the nucleoside reverse transcriptase inhibitor (NRTI) class, similar to drugs such as tenofovir and abacavir. Compared with tenofovir, lamivudine generally has a lower risk of renal toxicity but may be less potent in some HIV regimens. Choice of agent depends on resistance patterns, comorbidities and individual patient factors.
How should Lamivudina Accord be stored and handled?+
Lamivudina Accord should be stored at room temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the container tightly closed and out of reach of children. Do not store in humid or excessively hot environments.
How is Lamivudina Accord given or administered?+
Lamivudina Accord is administered orally as a tablet. The tablet should be swallowed whole with a glass of water and can be taken with or without food, unless otherwise directed by the prescriber. Patients should follow the dosing schedule prescribed by their healthcare provider.
What are the most serious risks to watch for while taking lamivudine?+
Serious adverse events associated with lamivudine include lactic acidosis, severe hepatomegaly with steatosis, and severe skin reactions such as Stevens‑Johnson syndrome or toxic epidermal necrolysis. Patients should seek immediate medical attention if they experience unexplained fatigue, abdominal pain, rapid weight loss, or any severe rash.
Who should not use Lamivudina Accord?+
Lamivudina Accord should not be used by individuals with a known hypersensitivity to lamivudine or any of its excipients. Caution is also advised in patients with severe hepatic impairment or those with pre‑existing mitochondrial disorders, as the risk of serious adverse reactions may be increased.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Lamivudine
Route
Oral Use
Manufacturer
Accord Healthcare S.L.U.
Origin
EU

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