Lamisil

Terbinafine, the active ingredient in Lamisil, is a allylamine antifungal presented as an oral dosage form for oral use. It treats dermatophyte infections of the skin and nails, such as athlete’s foot, ringworm, and fungal nail disease, in adult patients.

GNH USA supplies Lamisil as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable sourcing for global healthcare providers. Our distribution network ensures timely delivery and regulatory compliance across multiple regions.

Lamisil is an allylamine antifungal indicated for several dermatophyte infections. - Tinea pedis: relief of itching and eradication of the fungal infection on the feet. - Tinea corporis: treatment of ring‑shaped skin lesions caused by dermatophytes. - Onychomycosis: improvement of nail appearance and clearance of fungal invasion in the toenails or fingernails.

Terbinafine may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects: - Gastrointestinal upset: nausea, abdominal pain or dyspepsia. - Skin reactions: rash, pruritus or mild erythema. - Taste disturbances: loss of taste or a bitter taste sensation. - Headache: mild to moderate intensity.

Serious or Rare Side Effects: - Hepatotoxicity: elevated liver enzymes or hepatitis. - Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis. - Hematologic effects: neutropenia or eosinophilia. - Peripheral neuropathy: tingling or numbness in extremities.

Before prescribing Lamisil, clinicians should consider several precautionary measures to ensure safe use. - Liver function: assess baseline hepatic enzymes and monitor during therapy. - Drug interactions: review concomitant medications that affect CYP2D6 metabolism. - Renal impairment: adjust dose or monitor in patients with severe kidney disease. - Pregnancy and lactation: avoid use unless benefits outweigh potential risks. - Age considerations: use caution in elderly patients due to higher risk of adverse effects. - Store at ambient temperature: keep below 25 °C, retain in original packaging and protect from moisture.

Terbinafine can interact with other medicines, influencing its efficacy or safety.

Major Interactions (Avoid): - Itraconazole: combined use may increase risk of hepatotoxicity. - Cimetidine: may raise terbinafine plasma concentrations. - Rifampicin: can reduce terbinafine levels, diminishing antifungal effect.

Moderate Interactions (Monitor Closely): - Warfarin: may enhance anticoagulant effect, requiring INR monitoring. - Oral contraceptives: potential reduction in efficacy, advise alternative contraception. - Antidepressants metabolized by CYP2D6: monitor for altered plasma levels.