GNH USA

Europe — EMA

Lamisil (Terbinafine)

GNH USA supplies Lamisil (Terbinafine), a allylamine antifungal for tinea pedis, tinea corporis and onychomycosis. Request a quote for global supply.

Terbinafine

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What is Terbinafine?

Terbinafine, the active ingredient in Lamisil, is an allylamine antifungal presented as a tablet for oral use. It treats fungal infections of the skin, nails and related structures in patients as prescribed.

GNH USA supplies Lamisil as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Terbinafine used for?

Lamisil (terbinafine) is used to treat fungal infections affecting the skin, hair and nails.

- Tinea pedis: alleviates athlete's foot symptoms and eradicates the causative dermatophyte. - Tinea corporis: clears ringworm lesions on the body by eliminating the fungal infection. - Onychomycosis: improves nail appearance and clears fungal infection of the toenails or fingernails.

What are the side effects of Terbinafine?

Terbinafine may cause a range of adverse reactions, ranging from mild to serious.

Common Side Effects: - Gastrointestinal upset: nausea, abdominal pain or dyspepsia. - Skin reactions: rash, pruritus or mild erythema. - Taste disturbance: altered taste sensation or loss of taste. - Headache: mild to moderate headache episodes.

Serious or Rare Side Effects: - Hepatotoxicity: elevated liver enzymes or hepatitis. - Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis. - Hematologic effects: neutropenia or eosinophilia.

What precautions apply to Terbinafine?

Before initiating terbinafine therapy, consider the following safety measures.

- Liver function: assess baseline hepatic enzymes and monitor during treatment. - Drug metabolism: avoid use with strong CYP2D6 inhibitors that may increase terbinafine levels. - Pregnancy and lactation: safety not established; weigh benefits against potential risks. - Age considerations: use caution in elderly patients due to possible hepatic impairment. - Storage: Store at room temperature below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

What does Terbinafine interact with?

Terbinafine can interact with several medicines, altering its effectiveness or safety profile.

Major Interactions (Avoid): - Strong CYP2D6 inhibitors (e.g., fluoxetine, paroxetine): may increase terbinafine exposure. - Cimetidine: can raise terbinafine plasma concentrations. - Itraconazole or ketoconazole: combined use may enhance hepatotoxic risk.

Moderate Interactions (Monitor Closely): - Warfarin: terbinafine may potentiate anticoagulant effect, requiring INR monitoring. - Oral contraceptives: efficacy may be reduced, consider additional contraceptive methods. - Rifampin: may lower terbinafine levels, reducing antifungal efficacy.

Frequently asked questions

What conditions is Lamisil used to treat?+
Lamisil (terbinafine) is prescribed for fungal infections such as athlete's foot (tinea pedis), body ringworm (tinea corporis) and nail fungus (onychomycosis). It works by targeting the fungus that causes these skin and nail conditions, helping to clear infection and relieve symptoms.
How does terbinafine work to treat fungal infections?+
Terbinafine inhibits the fungal enzyme squalene epoxidase, which is essential for producing ergosterol, a key component of fungal cell membranes. Blocking this step leads to toxic squalene buildup and loss of ergosterol, disrupting the membrane and causing fungal cell death.
What is the usual dose of Lamisil?+
The dosage of Lamisil is determined by the prescribing clinician based on the specific infection, patient weight, age, liver function and other clinical factors. Patients should follow the prescriber’s instructions and not adjust the dose on their own.
Is Lamisil safe to use during pregnancy or breastfeeding?+
Safety data for terbinafine in pregnancy and lactation are limited, and the product is classified as having an unknown pregnancy category. Healthcare providers should evaluate the potential benefits against possible risks before prescribing it to pregnant or nursing individuals.
How do I order Lamisil from GNH USA?+
To request Lamisil, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.
How does Lamisil compare with other antifungal agents?+
Lamisil belongs to the allylamine class, which differs from azole antifungals that inhibit a later step in ergosterol synthesis. Terbinafine often achieves faster fungal clearance for dermatophyte infections and may be preferred for nail fungus due to its high tissue concentration, while azoles are commonly used for broader fungal spectra.
What are the storage requirements for Lamisil tablets?+
Lamisil tablets should be stored at room temperature below 25 °C, in the original packaging, protected from moisture and direct sunlight. Keeping the tablets in a dry, cool environment helps maintain their potency throughout the shelf life.
How is Lamisil administered to patients?+
Lamisil is taken orally, usually with a glass of water. The tablet should be swallowed whole and not chewed or crushed, unless the prescriber provides specific instructions for a particular formulation.
What are the most serious risks associated with Lamisil?+
Serious risks include liver injury, which may present as elevated liver enzymes or hepatitis, and severe skin reactions such as Stevens‑Johnson syndrome or toxic epidermal necrolysis. Patients should report any signs of jaundice, dark urine, rash or fever to their healthcare provider promptly.
Who should not use Lamisil?+
Individuals with known hypersensitivity to terbinafine or any component of the tablet should avoid Lamisil. Patients with pre‑existing severe liver disease, or those taking medications that strongly inhibit CYP2D6 without medical supervision, should also be evaluated carefully before use.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Terbinafine
Route
Oral Use
Manufacturer
Novartis Ireland Limited
Origin
EU

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