Lamictal

Lamotrigine, the active ingredient in Lamictal, is a Anticonvulsant presented as a tablet for Oral use. It treats epilepsy and bipolar disorder in adults.

GNH USA supplies Lamictal as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Lamotrigine is used in neurological and psychiatric conditions that involve abnormal neuronal excitability. - Epilepsy: reduces the frequency and severity of seizures. - Bipolar disorder: stabilises mood and helps prevent depressive episodes.

Lamotrigine may cause a range of adverse reactions, from mild to severe.

Common Side Effects: - Dizziness: transient light‑headedness or loss of balance. - Headache: mild to moderate pain often relieved with rest. - Nausea: upset stomach, sometimes with vomiting. - Rash: skin redness or itching, usually mild. - Blurred vision: temporary visual disturbances. - Fatigue: feeling unusually tired.

Serious or Rare Side Effects: - Stevens‑Johnson syndrome: severe skin reaction requiring immediate medical attention. - Toxic epidermal necrolysis: life‑threatening skin detachment. - Blood dyscrasias: abnormal blood counts such as agranulocytosis. - Hepatic failure: impaired liver function. - Severe skin reactions: including drug reaction with eosinophilia and systemic symptoms (DRESS). - Anaphylaxis: rare but potentially fatal allergic response.

Before initiating lamotrigine therapy, consider the following safety measures. - Pregnancy: safety unknown; discuss risks with a healthcare professional. - Renal impairment: dose may need adjustment based on kidney function. - History of skin reactions: avoid if previous severe rash occurred. - Concomitant valproate: increased risk of serious skin reactions; monitor closely. - Discontinuation: do not stop abruptly to prevent seizure worsening. - Store at ambient temperature: keep in the original pack, protect from moisture.

Lamotrigine interacts with several medicines that can alter its effectiveness or safety.

Major Interactions (Avoid): - Valproic acid: markedly increases risk of severe skin reactions. - Carbamazepine: reduces lamotrigine plasma concentrations, decreasing efficacy. - Phenobarbital: lowers lamotrigine levels, potentially compromising seizure control.

Moderate Interactions (Monitor Closely): - Oral contraceptives: increase lamotrigine clearance, possibly requiring dose adjustment. - Serotonergic agents: may raise the risk of serotonin syndrome. - Other antiepileptics: combined use may necessitate careful dose titration and monitoring.