Lamictal

Lamotrigine, the active ingredient in Lamictal, is a sodium channel blocker presented as an oral tablet for oral use. It is prescribed for the management of epilepsy and for mood stabilization in bipolar disorder.\n\nGNH India supplies Lamictal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Lamotrigine acts on neuronal sodium channels to control seizure activity and stabilize mood in bipolar disorder.\n\nEpilepsy: reduces the frequency and severity of seizures across various seizure types.\nBipolar disorder: provides maintenance therapy to prevent depressive and manic episodes.\nAdjunct therapy in refractory epilepsy: used alongside other antiepileptic drugs when seizures are not controlled by monotherapy.

Lamotrigine may cause a range of adverse reactions, from mild to severe.\n\nCommon Side Effects:\n- Dizziness\n- Headache\n- Nausea or vomiting\n- Skin rash\n- Insomnia\n- Blurred vision\n\nSerious or Rare Side Effects:\n- Stevens‑Johnson syndrome or toxic epidermal necrolysis\n- Severe skin reactions (e.g., bullous dermatitis)\n- Blood dyscrasias such as agranulocytosis\n- Hepatic failure\n- Anaphylactic reactions\n- Multi‑organ hypersensitivity syndrome

Lamotrigine requires careful monitoring and patient education to minimise risks.\n\nPregnancy: consult the prescriber as safety data are limited.\nRenal impairment: dose may need adjustment and renal function should be monitored.\nHepatic impairment: monitor liver enzymes and consider dose modification.\nConcomitant valproate: increased risk of severe skin reactions; dosage adjustments are recommended.\nAvoid abrupt discontinuation: may precipitate seizure recurrence or mood destabilisation.\nStore at ambient temperature: keep below 25 °C in the original packaging, protected from moisture and light.

Lamotrigine interacts with several medicines that can alter its plasma concentration or increase toxicity.\n\nMajor Interactions (Avoid):\n- Valproic acid: markedly raises lamotrigine levels and risk of serious skin reactions.\n- Carbamazepine: significantly reduces lamotrigine concentrations, potentially diminishing efficacy.\n\nModerate Interactions (Monitor Closely):\n- Oral contraceptives: may lower lamotrigine levels; dose adjustments might be needed.\n- Rifampin: induces metabolism, decreasing lamotrigine exposure.\n- Serotonergic agents (e.g., SSRIs): monitor for signs of serotonin syndrome.