Lafleur

Estradiol valerate and dienogest, the active ingredient in Lafleur, is a combined oral contraceptive presented as an oral tablet for oral use. It is indicated for contraception and for the management of endometriosis‑associated pain in women of reproductive age.

GNH USA supplies Lafleur as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Lafleur is a combined oral contraceptive that acts on the hormonal regulation of the menstrual cycle and provides pain relief in endometriosis. - Contraception: prevents pregnancy by inhibiting ovulation and altering cervical mucus. - Endometriosis‑associated pain: reduces pelvic pain by suppressing estrogen‑driven lesion activity. - Menstrual disorder management: helps regulate irregular bleeding and dysmenorrhea.

Common Side Effects: - Nausea: mild to moderate stomach upset. - Headache: tension‑type or migraine‑like. - Breast tenderness: swelling or discomfort. - Spotting: irregular light bleeding.

Serious or Rare Side Effects: - Venous thromboembolism: blood clots in deep veins. - Stroke: cerebrovascular accident due to clot formation. - Severe allergic reaction: anaphylaxis or angioedema.

Before prescribing Lafleur, consider the following precautions: - Cardiovascular risk assessment: evaluate history of thromboembolic events. - Smoking restriction: avoid use in women over 35 who smoke. - Blood pressure monitoring: watch for hypertension development. - Liver function review: contraindicated in severe hepatic disease. - Pregnancy testing: ensure patient is not pregnant before initiation. - Store at ambient temperature: keep in the original pack, protect from moisture.

Lafleur may interact with several medicines. Review patient medication lists carefully.

Major Interactions (Avoid): - Other estrogen‑containing products: increased clot risk. - Potent CYP3A4 inducers (e.g., rifampin): reduces contraceptive efficacy. - Anticoagulants (e.g., warfarin): may diminish anticoagulant effect. - Enzyme‑inducing antiepileptics (e.g., phenytoin): lower hormone levels.

Moderate Interactions (Monitor Closely): - Certain antibiotics (e.g., tetracycline): may slightly reduce effectiveness. - St. John’s wort: can decrease plasma hormone concentrations. - Antihypertensives: monitor blood pressure as contraceptives may affect control.