GNH USA

Europe — EMA

Lafadera

GNH USA supplies Lafadera (Dimethyl Fumarate), an immunomodulating agent for relapsing‑remitting multiple sclerosis and plaque psoriasis. Request a quote.

Dimethyl Fumarate

Request sourcing

1
Pack/s

What is Dimethyl Fumarate?

Dimethyl fumarate, the active ingredient in Lafadera, is a immunomodulating agent presented as an oral formulation for oral use. It is indicated for the treatment of relapsing‑remitting multiple sclerosis and plaque psoriasis in adults.

GNH USA supplies Lafadera as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Dimethyl Fumarate used for?

Dimethyl fumarate acts on immune‑mediated pathways, primarily in multiple sclerosis and psoriasis.

- Relapsing‑remitting multiple sclerosis: reduces relapse frequency and slows disability progression. - Plaque psoriasis: decreases skin lesion severity and body‑surface‑area involvement.

What are the side effects of Dimethyl Fumarate?

Common Side Effects: - Flushing: transient reddening and warmth, often mild. - Gastrointestinal upset: nausea, abdominal discomfort, or cramping. - Diarrhea: loose stools that may be mild to moderate. - Headache: occasional tension‑type headache.

Serious or Rare Side Effects: - Lymphopenia: significant reduction in lymphocyte count, requiring monitoring. - Hepatic injury: elevated liver enzymes or hepatitis in rare cases. - Severe hypersensitivity reactions: including rash, angioedema, or anaphylaxis.

What precautions apply to Dimethyl Fumarate?

Dimethyl fumarate requires regular monitoring of blood parameters and liver function. - Blood counts: monitor lymphocyte levels periodically to detect lymphopenia. - Liver function: assess transaminases before initiation and during therapy. - Infection risk: evaluate for active infections before starting treatment. - Pregnancy and lactation: safety not established; avoid unless benefits outweigh risks. - Storage: Store at ambient temperature below 25°C: keep in the original pack, protect from moisture.

What does Dimethyl Fumarate interact with?

Dimethyl fumarate may interact with several drug classes.

Major Interactions (Avoid): - Immunosuppressants (e.g., azathioprine, mycophenolate): increased risk of severe infections. - Live vaccines: may lead to inadequate immune response or infection.

Moderate Interactions (Monitor Closely):\n- Antacids: may alter gastrointestinal absorption, monitor efficacy. - NSAIDs: combined use can increase gastrointestinal irritation. - Non‑live vaccines: possible reduced immunogenicity, monitor response. - Alcohol: may exacerbate hepatic effects, advise moderation.

Frequently asked questions

What is Lafadera used for?+
Lafadera contains dimethyl fumarate and is approved for the treatment of relapsing‑remitting multiple sclerosis, where it helps lower the frequency of clinical relapses and slows disability progression, as well as for plaque psoriasis, where it reduces skin lesion severity and the extent of affected skin.
How does dimethyl fumarate work?+
Dimethyl fumarate activates the Nrf2 transcription factor, which up‑regulates antioxidant and cytoprotective genes. This reduces oxidative stress and modulates inflammatory cytokine production, leading to a tempered immune response that is beneficial in autoimmune diseases such as multiple sclerosis and psoriasis.
What is the usual dose of Lafadera?+
The dosage of Lafadera is determined by the prescribing clinician based on the individual’s condition, disease severity, and response to therapy. Physicians follow approved labeling and clinical guidelines to titrate the dose, and patients should follow the prescriber’s instructions without self‑adjustment.
Is Lafadera safe in pregnancy or breastfeeding?+
Safety of dimethyl fumarate in pregnancy and lactation has not been established. It is classified as pregnancy category unknown, and the drug should only be used if the potential benefit justifies the potential risk to the fetus. Breastfeeding mothers should consult their healthcare provider before use.
How do I order Lafadera from GNH USA?+
To order Lafadera, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements if applicable) and assists with import documentation.
How does Lafadera compare with the main alternative drug?+
The primary alternative to dimethyl fumarate is another oral disease‑modifying therapy such as fingolimod. While both reduce relapse rates in multiple sclerosis, dimethyl fumarate has a distinct mechanism via Nrf2 activation and a different safety profile, often associated with flushing and gastrointestinal effects, whereas fingolimod carries a higher risk of cardiac events and infections.
How should Lafadera be stored and handled?+
Lafadera should be stored at ambient temperature below 25 °C, in its original packaging, protected from moisture and direct sunlight. Keep the product out of reach of children and avoid exposing it to excessive heat or humidity to maintain stability.
How is Lafadera administered?+
Lafadera is taken orally, usually as a tablet swallowed whole with water. The exact administration schedule, including any titration phases, is set by the prescribing clinician and should be followed exactly as instructed.
What are the most serious risks to watch for while taking Lafadera?+
The most serious risks include significant lymphopenia, which can predispose to opportunistic infections; hepatic injury manifested by elevated liver enzymes; and rare severe hypersensitivity reactions such as anaphylaxis. Patients should report any signs of infection, jaundice, or allergic symptoms promptly.
Who should not use Lafadera?+
Lafadera is contraindicated in individuals with severe hepatic impairment, active serious infections, or known hypersensitivity to dimethyl fumarate or any excipients. It should also be used with caution, or avoided, in patients with severe immunosuppression, uncontrolled cardiac disease, or during pregnancy and breastfeeding unless clearly justified.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
Send a sourcing enquiry for this product →

Product details

Drug
Dimethyl Fumarate
Route
Oral Use
Manufacturer
Elpen Pharmaceutical Co. Inc.
Origin
EU

Related products

A

A

Liquid Extract From Viscum Album Subsp. Abietis Var Abies Alba (1:20), Extraction Solvents: Water Fo

Helixor Heilmittel Gmbh
EU
A

A

Liquid Extract From Viscum Album Subsp. Abietis Var Abies Alba (1:20), Extraction Solvents: Water Fo

Helixor Heilmittel Gmbh
EU
A

A

Liquid Extract From Viscum Album Subsp. Abietis Var Abies Alba (1:20), Extraction Solvents: Water Fo

Helixor Heilmittel Gmbh
EU
A

A

Liquid Extract From Viscum Album Subsp. Abietis Var Abies Alba (1:20), Extraction Solvents: Water Fo

Helixor Heilmittel Gmbh
EU