GNH USA

Europe — EMA

Ladurot (Tamsulosin Hydrochloride, Dutasteride)

GNH USA supplies Ladurot (Tamsulosin Hydrochloride and Dutasteride), an alpha‑1 adrenergic antagonist and 5‑alpha‑reductase inhibitor for benign prostatic

Tamsulosin Hydrochloride, Dutasteride

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What is Tamsulosin Hydrochloride, Dutasteride?

Tamsulosin hydrochloride and dutasteride, the active ingredient in Ladurot, is a alpha‑1 adrenergic antagonist / 5‑alpha‑reductase inhibitor presented as an oral tablet formulation for oral use. It treats benign prostatic hyperplasia in adult men by relieving urinary obstruction.

GNH USA supplies Ladurot as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Tamsulosin Hydrochloride, Dutasteride used for?

Ladurot combines tamsulosin and dutasteride to manage benign prostatic hyperplasia (BPH) and its associated urinary symptoms. - Benign prostatic hyperplasia (BPH): reduces prostate size and relaxes smooth muscle to improve urinary flow. - Lower urinary tract symptoms (LUTS) due to BPH: alleviates urgency, frequency and nocturia. - Prostate enlargement: decreases dihydrotestosterone‑driven growth, helping to prevent disease progression.

What are the side effects of Tamsulosin Hydrochloride, Dutasteride?

Ladurot may cause a range of adverse reactions, which are grouped by frequency and severity.

Common Side Effects: - Dizziness or light‑headedness. - Abnormal ejaculation or reduced libido. - Headache. - Nasal congestion. - Breast tenderness or enlargement.

Serious or Rare Side Effects: - Intraoperative floppy iris syndrome, which can complicate cataract surgery. - Severe allergic reactions such as rash, swelling or anaphylaxis. - Marked hypotension leading to fainting.

What precautions apply to Tamsulosin Hydrochloride, Dutasteride?

Before prescribing Ladurot, clinicians should consider several precautionary measures. - Renal or hepatic impairment: monitor liver function and adjust therapy if needed. - History of prostate cancer: evaluate risk‑benefit, as dutasteride may affect tumor markers. - Concurrent antihypertensive therapy: watch for additive blood‑pressure lowering effects. - Known hypersensitivity to tamsulosin, dutasteride or any excipients: avoid use. - Planned cataract surgery: inform surgeon of tamsulosin use due to risk of floppy iris syndrome. - Store at ambient temperature: keep in original packaging, protect from moisture and light.

What does Tamsulosin Hydrochloride, Dutasteride interact with?

Ladurot can interact with other medicines; some require avoidance while others need close monitoring.

Major Interactions (Avoid): - Potent CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may raise dutasteride plasma levels. - Other α‑blockers (e.g., prazosin, doxazosin): can cause additive hypotension.

Moderate Interactions (Monitor Closely): - CYP2D6 inhibitors (e.g., fluoxetine, paroxetine): may increase tamsulosin exposure. - Additional 5‑alpha‑reductase inhibitors (e.g., finasteride): may enhance hormonal effects. - Diuretics: may intensify orthostatic blood‑pressure drops.

Frequently asked questions

What is Ladurot used for?+
Ladurot is prescribed for the treatment of benign prostatic hyperplasia (BPH) in adult men. By combining two mechanisms—smooth‑muscle relaxation and reduction of prostate volume—it helps relieve urinary obstruction, decrease frequency, urgency and nocturia, and improve overall urinary flow.
How does tamsulosin and dutasteride work in Ladurot?+
Tamsulosin blocks α1A‑adrenergic receptors in the prostate and bladder neck, reducing dynamic muscle tone and easing urine passage. Dutasteride inhibits both type I and type II 5‑alpha‑reductase enzymes, lowering dihydrotestosterone production, which slows prostate growth and can shrink gland size over time.
What is the usual dose of Ladurot?+
The prescribed dose of Ladurot is determined by the treating physician based on the patient’s clinical condition, renal and hepatic function, and concomitant medications. Healthcare professionals follow local prescribing guidelines and adjust therapy as needed; patients should follow the prescriber’s instructions exactly.
Is Ladurot safe to use during pregnancy or breastfeeding?+
Ladurot is not indicated for use in pregnant or breastfeeding women. Safety data are limited, and the drug class may affect hormonal pathways. It is generally avoided in these populations, and alternative treatments should be considered under medical supervision.
How do I order Ladurot from GNH USA?+
To order Ladurot, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.
How does Ladurot compare with other BPH therapies?+
Ladurot combines an α‑blocker (tamsulosin) with a 5‑alpha‑reductase inhibitor (dutasteride), offering both rapid symptom relief and long‑term prostate size reduction. Compared with monotherapy, the combination can provide faster improvement in urinary flow while also decreasing the risk of disease progression, though it may carry a broader side‑effect profile.
What are the storage and handling requirements for Ladurot?+
Ladurot tablets should be stored at ambient temperature, below 25 °C, in the original blister pack or container. Protect the product from excess moisture, direct sunlight and heat. Keep out of reach of children and do not use after the expiry date printed on the packaging.
How is Ladurot administered?+
Ladurot is taken orally, usually once daily, with or without food as directed by the prescriber. Swallow the tablet whole with a glass of water; do not crush, chew, or split the tablet unless specifically instructed by a healthcare professional.
What are the most serious risks associated with Ladurot?+
Serious risks include intraoperative floppy iris syndrome, which can complicate cataract surgery, severe hypotension leading to fainting, and rare allergic reactions such as anaphylaxis. Patients should report sudden vision changes, severe dizziness, swelling, rash or difficulty breathing to their clinician promptly.
Who should not use Ladurot?+
Ladurot should be avoided in individuals with known hypersensitivity to tamsulosin, dutasteride, or any tablet excipients. Caution is advised for patients with severe liver disease, uncontrolled low blood pressure, or a history of prostate cancer where hormonal manipulation is contraindicated. Consultation with a physician is essential before starting therapy.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Tamsulosin Hydrochloride, Dutasteride
Route
Oral Use
Manufacturer
Cande Cz S.R.O.
Origin
EU

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