Lactulosum Polfarmex

Lactulose, the active ingredient in Lactulosum Polfarmex, is an osmotic laxative presented as an oral formulation for oral use. It is used to treat constipation and to reduce ammonia levels in patients with hepatic encephalopathy. GNH USA supplies Lactulosum Polfarmex as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Lactulose acts as an osmotic agent to relieve constipation and to manage hepatic encephalopathy by lowering intestinal ammonia. - Constipation: softens stool and promotes bowel movements, helping relieve occasional or chronic constipation. - Hepatic encephalopathy: reduces absorption of ammonia from the gut, assisting in the control of neuropsychiatric symptoms in liver disease patients.

Lactulose may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects: - Flatulence: increased gas production in the colon. - Abdominal cramping: discomfort due to increased intestinal activity. - Diarrhea: loose stools from excess osmotic water. - Nausea: mild stomach upset. - Bloating: sensation of fullness.

Serious or Rare Side Effects: - Electrolyte imbalance: especially low potassium from prolonged diarrhea. - Severe dehydration: excessive fluid loss requiring medical attention. - Allergic reaction: rash, itching, or swelling. - Hyperosmolar coma: extremely rare, associated with massive fluid shifts. - Hepatic encephalopathy worsening: paradoxical increase in ammonia in susceptible individuals.

Before using Lactulosum Polfarmex, consider the following safety measures. - Renal impairment: monitor fluid and electrolyte status closely. - Diabetes mellitus: watch for changes in blood glucose due to carbohydrate content. - Pediatric use: dosage must be individualized by a pediatric specialist. - Pregnancy and lactation: use only if clearly needed and prescribed by a physician. - Storage: Store below 25°C: keep in the original container, protect from moisture and direct sunlight.

Lactulose can interact with several medications, altering their effectiveness or safety profile.

Major Interactions (Avoid): - Antacids containing magnesium: may increase the laxative effect and cause diarrhea. - Metronidazole: concurrent use can enhance gastrointestinal side effects.

Moderate Interactions (Monitor Closely): - Diuretics: risk of electrolyte disturbances, especially potassium loss. - Insulin or oral hypoglycemics: carbohydrate content of lactulose may affect glucose control. - Antibiotics (broad‑spectrum): may alter gut flora, influencing lactulose metabolism. - Proton pump inhibitors: may modify gastric pH, affecting drug absorption. - Oral rehydration solutions: monitor total fluid intake to avoid overload.