Lactulosum Forte Polfarmex

Lactulose, the active ingredient in Lactulosum Forte, is an osmotic laxative presented as a pharmaceutical preparation for oral use. It is employed to relieve constipation and to manage hepatic encephalopathy by reducing ammonia absorption in patients with liver disease.

GNH USA supplies Lactulosum Forte as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide, ensuring consistent quality and regulatory compliance across markets.

Lactulosum Forte acts as an osmotic laxative and ammonia‑lowering agent in the gastrointestinal tract.

- Constipation: alleviates bowel stasis and promotes regular defecation. - Hepatic encephalopathy: lowers blood ammonia levels to improve neurological status. - Prevention of hepatic encephalopathy recurrence: maintains reduced ammonia concentrations to help avoid episodic deterioration.

Lactulose may cause a range of adverse reactions, most of which are related to its laxative action.

Common Side Effects: - Abdominal cramping - Flatulence - Diarrhoea - Nausea - Bloating - Increased thirst

Serious or Rare Side Effects: - Severe diarrhoea leading to dehydration - Electrolyte disturbances (e.g., hyponatraemia, hypokalaemia) - Allergic reactions such as rash or angioedema - Worsening hepatic encephalopathy in rare cases

When prescribing Lactulosum Forte, consider the following safety measures.

- Dose adjustment: in renal impairment, monitor fluid balance and electrolytes. - Avoid in galactosemia: lactulose contains galactose residues. - Monitor electrolytes: prolonged use may cause shifts in sodium or potassium. - Caution in paediatric patients: use only under medical supervision. - Pregnancy and lactation: assess risk‑benefit before use. - Store at ambient temperature: keep in the original pack, protect from moisture.

Lactulosum Forte can interact with other medicines, requiring attention to avoid reduced efficacy or increased toxicity.

Major Interactions (Avoid): - Antibiotics such as rifaximin: may diminish lactulose's ammonia‑lowering effect. - Other laxatives (e.g., bisacodyl): additive laxative action can cause severe diarrhoea. - Diuretics: increased risk of dehydration and electrolyte imbalance.

Moderate Interactions (Monitor Closely): - Antacids: may alter colonic pH and affect lactulose activity. - Metronidazole: may increase gastrointestinal side effects. - Oral hypoglycaemic agents: monitor blood glucose as rapid bowel movements can affect absorption.