Lactulose Viatris

Lactulose, the active ingredient in Lactulose Viatris, is an osmotic laxative presented as an oral preparation for gastrointestinal use. It is employed to treat constipation and to lower intestinal ammonia absorption in patients with hepatic encephalopathy.

GNH USA supplies Lactulose Viatris as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Lactulose is an osmotic laxative that acts on the gastrointestinal tract to manage two primary clinical conditions. - Constipation: softens stool and increases bowel frequency by drawing water into the intestinal lumen, facilitating easier passage. - Hepatic encephalopathy: reduces absorption of ammonia from the gut, helping to improve mental status in patients with liver disease.

Lactulose may cause a range of adverse reactions, most of which are mild and related to its osmotic activity.

Common Side Effects: - Abdominal bloating - Flatulence - Diarrhea - Nausea - Stomach cramps - Increased stool frequency

Serious or Rare Side Effects: - Severe electrolyte imbalance (e.g., hyponatremia) - Dehydration - Allergic reaction (rash, itching, swelling) - Severe abdominal pain - Rectal bleeding - Persistent vomiting

Lactulose should be used with attention to patient‑specific factors and proper storage. - Monitor electrolytes: especially in elderly or renal‑impaired patients. - Adjust dose in renal impairment: reduced clearance may increase risk of toxicity. - Caution in diabetes: the sugar content may affect blood glucose control. - Avoid abrupt discontinuation: may cause rebound constipation. - Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Lactulose can interact with other medicines, altering efficacy or safety.

Major Interactions (Avoid): - Concomitant use with other laxatives: may cause severe diarrhea and dehydration. - Antidiarrheal agents (e.g., loperamide): can reduce lactulose effectiveness and increase risk of colonic overload.

Moderate Interactions (Monitor Closely): - Antibiotics: may change gut flora and affect lactulose metabolism. - Oral hypoglycemic agents: monitor blood glucose due to carbohydrate content. - Mineral supplements (e.g., calcium, magnesium): may bind to lactulose and reduce its osmotic effect.