Lactulose Hexal

Lactulose, the active ingredient in Lactulose Hexal, is an osmotic laxative presented as an oral formulation for oral use. The compound works by increasing the osmotic pressure within the intestinal lumen, drawing water into the colon to soften stools and promote bowel movements, while also converting intestinal ammonia to ammonium for excretion. It is employed to relieve constipation and to reduce ammonia absorption in patients with hepatic encephalopathy.

GNH USA supplies Lactulose Hexal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Lactulose is used as an osmotic laxative to manage conditions related to bowel motility and hepatic ammonia accumulation.

Constipation: softens stool and increases bowel movement frequency, helping to relieve occasional or chronic constipation. Hepatic encephalopathy: lowers intestinal ammonia production and absorption, supporting the management of hepatic encephalopathy in patients with liver disease.

Lactulose may cause a range of adverse reactions, most of which are related to its laxative action.

Common Side Effects: - Abdominal bloating - Flatulence - Diarrhea - Nausea

Serious or Rare Side Effects: - Severe electrolyte imbalance (e.g., hyponatremia, hypokalemia) - Allergic reaction such as rash, itching or swelling - Intense abdominal pain or rectal bleeding

When prescribing lactulose, several precautionary measures should be considered to ensure safe use. - Assess renal function: monitor for potential accumulation in patients with severe renal impairment. - Monitor electrolytes: watch for imbalances due to fluid loss from diarrhea. - Use caution in diabetic patients: lactulose contains small amounts of sugar that may affect glucose control. - Avoid in intestinal obstruction: the drug can exacerbate blockage. - Store at room temperature: keep in the original container, protect from moisture.

Lactulose can interact with other medicines, affecting their efficacy or safety.

Major Interactions (Avoid): - Concurrent use with other strong laxatives: may cause severe dehydration and electrolyte loss. - Broad‑spectrum antibiotics that alter gut flora: may reduce lactulose’s conversion to acids and diminish its effect.

Moderate Interactions (Monitor Closely): - Antidiabetic agents: lactulose may interfere with glucose monitoring, requiring dose adjustments. - Mineral supplements (e.g., magnesium, calcium): can increase osmotic load and risk of diarrhea. - Probiotic preparations: may modify colonic fermentation and affect lactulose activity.