Lactulose Generis

Lactulose, the active ingredient in Lactulose Generis, is an osmotic laxative presented as an oral dosage form for oral use. It treats constipation and hepatic encephalopathy in adult patients. It works by drawing water into the colon, softening stool and reducing ammonia absorption, making it useful in liver disease management.

GNH USA supplies Lactulose Generis as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to EU quality standards and provides regulatory documentation for export, ensuring reliable sourcing for healthcare providers.

Lactulose is an osmotic laxative that acts on bowel motility and ammonia metabolism.

- Constipation: relieves infrequent bowel movements and hard stools by increasing colonic water content. - Hepatic encephalopathy: lowers blood ammonia levels, improving mental status in patients with liver dysfunction. - Pediatric constipation: provides gentle laxation for children with functional constipation.

Lactulose may cause a range of gastrointestinal and systemic reactions, most of which are mild and transient.

Common Side Effects: - Abdominal bloating - Flatulence - Diarrhea - Nausea

Serious or Rare Side Effects: - Severe electrolyte imbalance - Dehydration - Allergic reaction (rash, itching, swelling)

When prescribing lactulose, clinicians should consider several safety aspects to minimize risk.

- Renal function assessment: evaluate kidney status before initiating therapy. - Electrolyte monitoring: check serum electrolytes periodically, especially in long‑term use. - Diabetes caution: monitor blood glucose as lactulose may affect carbohydrate balance. - Intestinal obstruction avoidance: do not use in patients with known bowel blockage. - Hepatic impairment adjustment: use lowest effective dose in severe liver disease. - Store at ambient temperature: keep in the original container, protect from moisture and heat.

Lactulose can interact with other medicines, altering its efficacy or increasing adverse effects.

Major Interactions (Avoid): - Antacids containing magnesium: may increase osmotic load and worsen diarrhea. - Loop diuretics: combined use can heighten risk of electrolyte disturbances.

Moderate Interactions (Monitor Closely): - Antibiotics that alter gut flora (e.g., rifaximin): may reduce lactulose fermentation and effectiveness. - Probiotics: concurrent use may modify colonic bacterial activity, affecting drug action. - Oral rehydration solutions: monitor fluid and electrolyte balance when used together.