Lactulose Eg

Lactulose, the active ingredient in Lactulose Eg, is an osmotic laxative presented as an oral solution for oral administration. It works by drawing water into the intestinal lumen, thereby softening stools and reducing ammonia absorption, and is indicated for the treatment of constipation and the management of hepatic encephalopathy in adult patients.

GNH USA supplies Lactulose Eg as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, providing reliable sourcing for global healthcare markets.

Lactulose is an osmotic laxative that acts on the gastrointestinal tract to relieve constipation and lower ammonia levels in liver disease. - Constipation: softens stool and promotes regular bowel movements. - Hepatic encephalopathy: reduces intestinal ammonia absorption, helping to improve neurological symptoms.

Lactulose may cause a range of adverse reactions, most of which are related to its osmotic activity in the gut.

Common Side Effects: - Abdominal bloating - Flatulence - Diarrhea - Nausea - Abdominal cramps - Increased thirst

Serious or Rare Side Effects: - Severe electrolyte imbalance (e.g., hyponatremia, hypokalemia) - Dehydration - Allergic reactions such as rash or urticaria - Severe abdominal pain - Hypovolemia - Rare cases of colonic perforation

When prescribing Lactulose, clinicians should consider several safety precautions to minimize risks. - Dose adjustment: Reduce dose in patients with renal impairment or severe liver disease. - Electrolyte monitoring: Check serum electrolytes regularly during prolonged therapy. - Diabetes caution: Monitor blood glucose as Lactulose may affect carbohydrate metabolism. - Obstruction warning: Avoid use in patients with known intestinal obstruction or perforation. - Fluid balance: Ensure adequate hydration to prevent dehydration. - Store at ambient temperature: Keep below 25 °C in the original container, protected from moisture and light.

Lactulose can interact with other medicines, influencing efficacy or safety.

Major Interactions (Avoid): - Concomitant use with strong laxatives (e.g., senna, bisacodyl) may cause severe diarrhea and electrolyte loss. - Co‑administration with diuretics can exacerbate dehydration and electrolyte disturbances.

Moderate Interactions (Monitor Closely): - Antibiotics that alter gut flora (e.g., rifaximin) may modify Lactulose’s effect on ammonia production. - Probiotic supplements may reduce the osmotic effect of Lactulose. - Antacids containing magnesium may increase gastrointestinal side effects. - Antidiarrheal agents (e.g., loperamide) may diminish Lactulose’s intended laxative action.