GNH USA

Europe — EMA

Lacosamide Fresenius Kabi

GNH USA supplies Lacosamide Fresenius Kabi (Lacosamide), a sodium channel blocker for adjunctive therapy of partial‑onset seizures in epilepsy.

Lacosamide

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What is Lacosamide?

Lacosamide, the active ingredient in Lacosamide Fresenius Kabi, is a sodium channel blocker presented as a solution for injection for intravenous use. It treats partial‑onset seizures as adjunctive therapy in patients with epilepsy.

GNH USA supplies Lacosamide Fresenius Kabi as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

What is Lacosamide used for?

Lacosamide is an antiepileptic agent that modulates neuronal excitability in seizure disorders.

Partial‑onset seizures: adjunctive therapy to reduce seizure frequency. Focal seizures with secondary generalisation: adjunctive therapy to improve overall seizure control. Epilepsy (overall): contributes to comprehensive seizure management as part of combination therapy.

What are the side effects of Lacosamide?

Lacosamide may cause a range of adverse reactions, most of which are mild to moderate in severity.

Common Side Effects: - Dizziness: transient sensation of light‑headedness. - Nausea: mild gastrointestinal upset. - Headache: occasional tension‑type headache. - Fatigue: feeling of tiredness or reduced energy. - Blurred vision: temporary visual disturbances. - Diplopia: double vision in some patients.

Serious or Rare Side Effects: - Cardiac conduction abnormalities: PR‑interval prolongation or arrhythmia. - Suicidal ideation: emergence of depressive thoughts or behaviours. - Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis. - Respiratory depression: especially when combined with other CNS depressants.

What precautions apply to Lacosamide?

Before initiating therapy, clinicians should evaluate patient‑specific factors and monitor for potential complications.

Renal impairment: assess renal function and consider dose adjustment. Hepatic impairment: use with caution in patients with liver disease. Cardiac conduction disorders: monitor ECG for PR‑interval changes. Concomitant CNS depressants: evaluate additive sedation risk. Pregnancy: safety data are limited; discuss risks with the patient. Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

What does Lacosamide interact with?

Lacosamide may interact with other medicines, requiring careful management.

Major Interactions (Avoid): - Class I antiarrhythmics: may exacerbate PR‑interval prolongation. - Strong CYP3A4 inhibitors (e.g., ketoconazole): increase lacosamide plasma levels. - Strong CYP3A4 inducers (e.g., rifampicin): reduce lacosamide exposure.

Moderate Interactions (Monitor Closely): - Other antiepileptic drugs: may require dose adjustments to maintain efficacy. - Alcohol: additive central nervous system depression. - Tricyclic antidepressants: potential increase in cardiac effects.

Frequently asked questions

What is Lacosamide Fresenius Kabi used for?+
Lacosamide Fresenius Kabi is an intravenous formulation of the antiepileptic drug lacosamide. It is prescribed as adjunctive therapy for partial‑onset (focal) seizures in patients with epilepsy, helping to reduce the frequency of seizure episodes when added to existing antiseizure regimens.
How does lacosamide work?+
Lacosamide enhances the slow inactivation of voltage‑gated sodium channels in neuronal membranes. This stabilises hyper‑excitable neurons and limits repetitive firing, thereby decreasing the likelihood of seizure propagation without markedly affecting normal rapid sodium channel activity.
What is the usual dose of Lacosamide Fresenius Kabi?+
The specific dosing regimen for Lacosamide Fresenius Kabi is determined by the prescribing clinician based on the patient’s clinical condition, age, renal function and concomitant therapies. Healthcare professionals should follow local prescribing guidelines and adjust the dose as needed.
Is Lacosamide safe during pregnancy or breastfeeding?+
Safety data for lacosamide in pregnancy and lactation are limited. The medication should only be used if the potential benefit justifies the potential risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss treatment options with their healthcare provider.
How do I order Lacosamide Fresenius Kabi from GNH USA?+
To place an order, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain handling if needed) and required import documentation.
How does Lacosamide compare with other antiepileptic drugs?+
Lacosamide differs from many traditional antiepileptics such as carbamazepine or phenytoin by selectively enhancing the slow inactivation of sodium channels, which may result in a distinct side‑effect profile and fewer drug‑enzyme interactions. Compared with levetiracetam, lacosamide offers an alternative mechanism for patients who do not achieve adequate control with other agents.
What are the storage and handling requirements for Lacosamide Fresenius Kabi?+
Lacosamide Fresenius Kabi should be stored refrigerated at 2‑8 °C. Keep the vials in their original packaging, protect them from light, and avoid freezing or shaking the solution. If the product reaches room temperature, it may be used within the time frame specified in the product label.
How is Lacosamide Fresenius Kabi administered?+
The medication is given by intravenous injection or infusion under the supervision of a qualified healthcare professional. The rate of administration and dilution instructions are provided in the prescribing information and should be followed to ensure safe and effective delivery.
What are the most serious risks associated with Lacosamide?+
Serious adverse events include cardiac conduction abnormalities such as PR‑interval prolongation, which can lead to arrhythmias, as well as rare but severe skin reactions (e.g., Stevens‑Johnson syndrome) and the emergence of suicidal thoughts or behaviours. Prompt medical evaluation is required if any of these occur.
Who should not use Lacosamide Fresenius Kabi?+
Lacosamide is contraindicated in individuals with known hypersensitivity to the drug or any of its excipients. Patients with significant cardiac conduction disorders (e.g., second‑degree AV block) should avoid use unless closely monitored, as the medication can exacerbate PR‑interval prolongation.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Lacosamide
Route
Intravenous Use
Manufacturer
Fresenius Kabi Polska Sp. Z O.O.
Origin
EU

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