Lacerol Retard

Diltiazem, the active ingredient in Lacerol Retard, is a calcium channel blocker presented as an oral formulation for oral use. It is employed to manage hypertension, angina pectoris, and to control heart rate in atrial fibrillation, particularly in adult patients.

GNH USA supplies Lacerol Retard as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable sourcing for regulated markets. Our distribution network ensures timely delivery and compliance with local regulatory requirements.

Diltiazem is a calcium channel blocker used to treat cardiovascular conditions.

Hypertension: lowers blood pressure by reducing peripheral vascular resistance. Angina pectoris: relieves chest pain by decreasing myocardial oxygen demand. Rate control in atrial fibrillation: slows ventricular response by inhibiting atrioventricular nodal conduction.

Common Side Effects: - Headache: mild to moderate intensity. - Dizziness or light‑headedness, especially when standing. - Flushing: sensation of warmth and redness. - Peripheral edema: swelling of the ankles or feet. - Constipation or mild gastrointestinal discomfort. - Nausea: occasional upset stomach.

Serious or Rare Side Effects: - Severe hypotension: marked drop in blood pressure. - Bradycardia: abnormally slow heart rate. - Heart block: impairment of electrical conduction. - Hepatic enzyme elevation: abnormal liver function tests. - Allergic reactions: rash, itching, or swelling. - Pulmonary edema: fluid accumulation in the lungs.

Before initiating therapy, consider the following precautions. - Blood pressure monitoring: ensure baseline and periodic measurements. - Cardiac function assessment: evaluate for existing conduction abnormalities. - Drug interaction review: check concomitant medications that affect heart rate or blood pressure. - Hepatic impairment: adjust use in patients with liver disease. - Abrupt discontinuation: taper dose to avoid rebound hypertension. - Store at room temperature: keep in the original pack, protect from moisture.

Diltiazem may interact with several medicines; awareness helps prevent adverse outcomes.

Major Interactions (Avoid):\n- Beta‑blockers: combined use can cause excessive bradycardia. - Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): increase diltiazem plasma levels. - Digoxin: elevated digoxin concentrations may occur.

Moderate Interactions (Monitor Closely): - CYP3A4 inducers (e.g., rifampin, carbamazepine): may reduce diltiazem effectiveness. - Diuretics: additive hypotensive effect. - NSAIDs: may diminish antihypertensive response. - Alcohol: can enhance dizziness and hypotension. - Grapefruit juice: may modestly increase diltiazem exposure.