GNH USA

Europe — EMA

Krenosin

GNH USA supplies Krenosin (Adenosine), a nucleoside antiarrhythmic for PSVT and diagnostic stress testing via injection. Request a quote for global supply.

Adenosine

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What is Adenosine?

Adenosine, the active ingredient in Krenosin, is a nucleoside antiarrhythmic presented as an injection solution for intravenous use. It treats paroxysmal supraventricular tachycardia and is used in diagnostic stress testing.

GNH USA supplies Krenosin as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals worldwide.

What is Adenosine used for?

Krenosin is a nucleoside antiarrhythmic that acts on the atrioventricular (AV) node to terminate rapid supraventricular rhythms.

Paroxysmal supraventricular tachycardia (PSVT): rapid conversion to sinus rhythm. Diagnostic stress testing: transient AV block to assess coronary flow reserve.

What are the side effects of Adenosine?

Adverse reactions may occur after intravenous administration.

Common Side Effects: - Flushing or warmth sensation. - Chest discomfort or pressure. - Shortness of breath. - Transient hypotension. - Facial pallor.

Serious or Rare Side Effects: - Prolonged AV block or severe bradycardia. - Asystole or cardiac arrest. - Allergic reactions including bronchospasm. - Seizures (rare). - Pulmonary edema (very rare).

What precautions apply to Adenosine?

Krenosin should be used with caution in specific clinical situations.

Pregnancy: Category B – use only if benefit outweighs potential risk. Breastfeeding: Caution – limited data, consider infant exposure. Second- or third-degree AV block: Avoid use. Concomitant AV nodal blockers (e.g., dipyridamole): May potentiate effects. Severe coronary artery disease: Monitor for ischemic symptoms. Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

What does Adenosine interact with?

Adenosine may interact with several cardiovascular agents.

Major Interactions (Avoid): - Second- or third-degree AV block. - Sick sinus syndrome. - Severe coronary artery disease. - Concomitant dipyridamole.

Moderate Interactions (Monitor Closely): - Beta‑blockers. - Calcium channel blockers. - Theophylline.

Frequently asked questions

What is Krenosin used for?+
Krenosin contains adenosine and is used to terminate episodes of paroxysmal supraventricular tachycardia (PSVT) and to produce a brief, controlled AV block during diagnostic stress testing of the coronary circulation.
How does adenosine work in Krenosin?+
Adenosine activates A1 receptors in the heart, causing potassium efflux and hyperpolarization of AV nodal cells. This creates a short, reversible block of AV conduction, which stops re‑entrant tachyarrhythmias and provides a transient stimulus for stress testing.
What is the usual dose of Krenosin?+
The dose of Krenosin is determined by the prescribing clinician based on the patient’s condition, weight, and response. It is administered intravenously as a rapid bolus under continuous cardiac monitoring.
Is Krenosin safe during pregnancy or breastfeeding?+
Adenosine is classified as Pregnancy Category B, indicating that animal studies have not shown risk but there are no well‑controlled human studies. It should be used only if the potential benefit justifies the potential risk to the fetus. Breastfeeding mothers should consult a healthcare professional.
How do I order Krenosin from GNH USA?+
To order Krenosin, submit an enquiry on the product page at gnh-usa.com with the required quantity. GNH USA supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.
How does Krenosin compare with other antiarrhythmic agents?+
Unlike class I or III antiarrhythmics, adenosine works almost instantly and has a very short half‑life, making it ideal for rapid conversion of PSVT and for controlled AV block during stress testing. Its effect wears off within seconds, reducing the need for prolonged monitoring compared with longer‑acting agents.
What are the storage requirements for Krenosin?+
Krenosin should be stored at 2‑8 °C (refrigerated). Keep the vial in its original packaging, protect it from light, and do not freeze or shake the solution to maintain stability.
How is Krenosin administered?+
Krenosin is given as an intravenous bolus injection, typically through a peripheral vein. Administration should be performed by trained healthcare personnel with continuous ECG monitoring to observe the rapid onset and termination of the AV block.
What are the most serious risks associated with Krenosin?+
The most serious risks include prolonged AV block, severe bradycardia, asystole, and rare allergic reactions such as bronchospasm. Immediate medical intervention, including atropine or transcutaneous pacing, may be required if these events occur.
Who should not use Krenosin?+
Krenosin is contraindicated in patients with second‑ or third‑degree AV block, sick sinus syndrome, or severe coronary artery disease without appropriate monitoring. It should also be avoided in individuals with known hypersensitivity to adenosine or any of its excipients.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Adenosine
Route
Intravenous Use
Manufacturer
Sanofi S.R.L.
Origin
EU

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