GNH USA

Europe — EMA

Kostarox (Etoricoxib)

GNH USA supplies Kostarox (Etoricoxib), a COX-2 selective NSAID for osteoarthritis, rheumatoid arthritis and acute pain. Request a quote for global supply.

Etoricoxib

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What is Etoricoxib?

Etoricoxib, the active ingredient in Kostarox, is a COX-2 selective NSAID presented as an oral dosage form for oral use. It is indicated for the management of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute pain and gout in adult patients. GNH USA supplies Kostarox as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Etoricoxib used for?

Kostarox (etoricoxib) is a COX‑2 selective NSAID used to treat several inflammatory and painful conditions. - Osteoarthritis: reduces joint pain and improves mobility. - Rheumatoid arthritis: alleviates synovial inflammation and pain. - Ankylosing spondylitis: decreases spinal inflammation and stiffness. - Acute pain: provides rapid relief of moderate to severe pain. - Gout: helps control pain and inflammation during acute gout attacks.

What are the side effects of Etoricoxib?

Etoricoxib may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects: - Headache: mild to moderate intensity. - Gastrointestinal discomfort: nausea, dyspepsia or abdominal pain. - Hypertension: increase in blood pressure readings. - Peripheral edema: swelling of the lower limbs. - Dizziness: transient light‑headedness.

Serious or Rare Side Effects: - Cardiovascular events: myocardial infarction or stroke. - Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis. - Hepatic impairment: elevated liver enzymes or hepatitis.

What precautions apply to Etoricoxib?

Before prescribing Kostarox, clinicians should consider several safety aspects. - Cardiovascular risk: assess history of heart disease or stroke. - Gastrointestinal history: evaluate prior ulcers or bleeding. - Renal function: monitor creatinine in patients with kidney disease. - Concomitant drugs: review use of anticoagulants, other NSAIDs or corticosteroids. - Pregnancy and lactation: avoid unless benefits outweigh risks. - Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture.

What does Etoricoxib interact with?

Etoricoxib can interact with several drug classes, requiring careful management.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased bleeding risk. - Other NSAIDs or COX‑2 inhibitors: additive gastrointestinal toxicity. - Selective serotonin reuptake inhibitors (SSRIs): heightened hemorrhage potential.

Moderate Interactions (Monitor Closely): - Antihypertensives (ACE inhibitors, ARBs, diuretics): possible reduction in blood‑pressure control. - Lithium: risk of lithium toxicity due to reduced renal clearance. - Methotrexate: potential for increased methotrexate levels.

Frequently asked questions

What conditions is Kostarox used to treat?+
Kostarox contains etoricoxib, a COX‑2 selective NSAID indicated for osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute pain and gout. It helps reduce inflammation and relieve pain associated with these disorders.
How does etoricoxib work in the body?+
Etoricoxib selectively blocks the cyclooxygenase‑2 enzyme, decreasing the synthesis of prostaglandins that cause inflammation, pain and fever. By sparing COX‑1, it preserves protective gastric prostaglandins while providing anti‑inflammatory and analgesic effects.
What is the usual dose of Kostarox?+
The appropriate dose of Kostarox is determined by the prescribing healthcare professional based on the patient’s condition, severity, and individual response. Patients should follow the prescriber’s instructions and not adjust the dose on their own.
Is Kostarox safe to use during pregnancy or breastfeeding?+
Safety of etoricoxib in pregnancy or lactation has not been established. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and only under medical supervision.
How do I order Kostarox from GNH USA?+
To order Kostarox, submit an enquiry on the product page at gnh-usa.com specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.
How does Kostarox compare with other NSAIDs?+
Kostarox (etoricoxib) is a COX‑2 selective NSAID, offering similar pain‑relieving and anti‑inflammatory benefits as non‑selective NSAIDs but with a lower risk of gastrointestinal irritation. However, it may carry a higher cardiovascular risk, which should be weighed against other options.
What are the recommended storage conditions for Kostarox?+
Kostarox should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and store out of reach of children.
How is Kostarox administered?+
Kostarox is taken orally, usually with a full glass of water. It can be taken with or without food, but patients should follow the specific instructions provided by their prescriber.
What are the most serious risks associated with Kostarox?+
Serious risks include cardiovascular events such as heart attack or stroke, severe skin reactions like Stevens‑Johnson syndrome, and significant liver or kidney impairment. Patients should seek immediate medical attention if they experience chest pain, rash, jaundice or sudden swelling.
Who should not use Kostarox?+
Kostarox should be avoided in patients with known hypersensitivity to etoricoxib or other NSAIDs, those with active gastrointestinal bleeding, severe heart failure, recent myocardial infarction, or uncontrolled hypertension. It is also contraindicated in patients with severe liver or kidney disease unless specifically directed by a physician.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Etoricoxib
Route
Oral Use
Manufacturer
S.C. Sandoz S.R.L.
Origin
EU

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